Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms

Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were de...

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Detalles Bibliográficos
Autores principales: Chen, Shuqiang, Dong, Guoqiang, Wu, Shanchao, Liu, Na, Zhang, Wannian, Sheng, Chunquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361730/
https://www.ncbi.nlm.nih.gov/pubmed/30766786
http://dx.doi.org/10.1016/j.apsb.2018.08.003
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author Chen, Shuqiang
Dong, Guoqiang
Wu, Shanchao
Liu, Na
Zhang, Wannian
Sheng, Chunquan
author_facet Chen, Shuqiang
Dong, Guoqiang
Wu, Shanchao
Liu, Na
Zhang, Wannian
Sheng, Chunquan
author_sort Chen, Shuqiang
collection PubMed
description Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms.
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spelling pubmed-63617302019-02-14 Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms Chen, Shuqiang Dong, Guoqiang Wu, Shanchao Liu, Na Zhang, Wannian Sheng, Chunquan Acta Pharm Sin B Original article Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these compounds has been hampered by a poor understanding of their antitumor mechanisms. To tackle this obstacle, herein, novel fluorescent probes were designed to elucidate the antitumor mode of action of 10-hydroxyevodiamine. This compound was proven to be distributed in the mitochondria and lysosomes and to act by autophagy and apoptosis mechanisms. Elsevier 2019-01 2018-08-20 /pmc/articles/PMC6361730/ /pubmed/30766786 http://dx.doi.org/10.1016/j.apsb.2018.08.003 Text en © 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original article
Chen, Shuqiang
Dong, Guoqiang
Wu, Shanchao
Liu, Na
Zhang, Wannian
Sheng, Chunquan
Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
title Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
title_full Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
title_fullStr Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
title_full_unstemmed Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
title_short Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
title_sort novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms
topic Original article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361730/
https://www.ncbi.nlm.nih.gov/pubmed/30766786
http://dx.doi.org/10.1016/j.apsb.2018.08.003
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