Orexin in the anxiety spectrum: association of a HCRTR1 polymorphism with panic disorder/agoraphobia, CBT treatment response and fear-related intermediate phenotypes

Preclinical studies point to a pivotal role of the orexin 1 (OX(1)) receptor in arousal and fear learning and therefore suggest the HCRTR1 gene as a prime candidate in panic disorder (PD) with/without agoraphobia (AG), PD/AG treatment response, and PD/AG-related intermediate phenotypes. Here, a mult...

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Detalles Bibliográficos
Autores principales: Gottschalk, Michael G., Richter, Jan, Ziegler, Christiane, Schiele, Miriam A., Mann, Julia, Geiger, Maximilian J., Schartner, Christoph, Homola, György A., Alpers, Georg W., Büchel, Christian, Fehm, Lydia, Fydrich, Thomas, Gerlach, Alexander L., Gloster, Andrew T., Helbig-Lang, Sylvia, Kalisch, Raffael, Kircher, Tilo, Lang, Thomas, Lonsdorf, Tina B., Pané-Farré, Christiane A., Ströhle, Andreas, Weber, Heike, Zwanzger, Peter, Arolt, Volker, Romanos, Marcel, Wittchen, Hans-Ulrich, Hamm, Alfons, Pauli, Paul, Reif, Andreas, Deckert, Jürgen, Neufang, Susanne, Höfler, Michael, Domschke, Katharina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361931/
https://www.ncbi.nlm.nih.gov/pubmed/30718541
http://dx.doi.org/10.1038/s41398-019-0415-8

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