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Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors
Recent studies showed that changes to the gut microbiome alters the microbiome-derived metabolome, potentially promoting carcinogenesis in organs that are distal to the gut. In this study, we assessed the relationship between breast cancer and cadaverine biosynthesis. Cadaverine treatment of Balb/c...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361949/ https://www.ncbi.nlm.nih.gov/pubmed/30718646 http://dx.doi.org/10.1038/s41598-018-37664-7 |
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author | Kovács, Tünde Mikó, Edit Vida, András Sebő, Éva Toth, Judit Csonka, Tamás Boratkó, Anita Ujlaki, Gyula Lente, Gréta Kovács, Patrik Tóth, Dezső Árkosy, Péter Kiss, Borbála Méhes, Gábor Goedert, James J. Bai, Péter |
author_facet | Kovács, Tünde Mikó, Edit Vida, András Sebő, Éva Toth, Judit Csonka, Tamás Boratkó, Anita Ujlaki, Gyula Lente, Gréta Kovács, Patrik Tóth, Dezső Árkosy, Péter Kiss, Borbála Méhes, Gábor Goedert, James J. Bai, Péter |
author_sort | Kovács, Tünde |
collection | PubMed |
description | Recent studies showed that changes to the gut microbiome alters the microbiome-derived metabolome, potentially promoting carcinogenesis in organs that are distal to the gut. In this study, we assessed the relationship between breast cancer and cadaverine biosynthesis. Cadaverine treatment of Balb/c female mice (500 nmol/kg p.o. q.d.) grafted with 4T1 breast cancer cells ameliorated the disease (lower mass and infiltration of the primary tumor, fewer metastases, and lower grade tumors). Cadaverine treatment of breast cancer cell lines corresponding to its serum reference range (100–800 nM) reverted endothelial-to-mesenchymal transition, inhibited cellular movement and invasion, moreover, rendered cells less stem cell-like through reducing mitochondrial oxidation. Trace amino acid receptors (TAARs), namely, TAAR1, TAAR8 and TAAR9 were instrumental in provoking the cadaverine-evoked effects. Early stage breast cancer patients, versus control women, had reduced abundance of the CadA and LdcC genes in fecal DNA, both responsible for bacterial cadaverine production. Moreover, we found low protein expression of E. coli LdcC in the feces of stage 1 breast cancer patients. In addition, higher expression of lysine decarboxylase resulted in a prolonged survival among early-stage breast cancer patients. Taken together, cadaverine production seems to be a regulator of early breast cancer. |
format | Online Article Text |
id | pubmed-6361949 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63619492019-02-06 Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors Kovács, Tünde Mikó, Edit Vida, András Sebő, Éva Toth, Judit Csonka, Tamás Boratkó, Anita Ujlaki, Gyula Lente, Gréta Kovács, Patrik Tóth, Dezső Árkosy, Péter Kiss, Borbála Méhes, Gábor Goedert, James J. Bai, Péter Sci Rep Article Recent studies showed that changes to the gut microbiome alters the microbiome-derived metabolome, potentially promoting carcinogenesis in organs that are distal to the gut. In this study, we assessed the relationship between breast cancer and cadaverine biosynthesis. Cadaverine treatment of Balb/c female mice (500 nmol/kg p.o. q.d.) grafted with 4T1 breast cancer cells ameliorated the disease (lower mass and infiltration of the primary tumor, fewer metastases, and lower grade tumors). Cadaverine treatment of breast cancer cell lines corresponding to its serum reference range (100–800 nM) reverted endothelial-to-mesenchymal transition, inhibited cellular movement and invasion, moreover, rendered cells less stem cell-like through reducing mitochondrial oxidation. Trace amino acid receptors (TAARs), namely, TAAR1, TAAR8 and TAAR9 were instrumental in provoking the cadaverine-evoked effects. Early stage breast cancer patients, versus control women, had reduced abundance of the CadA and LdcC genes in fecal DNA, both responsible for bacterial cadaverine production. Moreover, we found low protein expression of E. coli LdcC in the feces of stage 1 breast cancer patients. In addition, higher expression of lysine decarboxylase resulted in a prolonged survival among early-stage breast cancer patients. Taken together, cadaverine production seems to be a regulator of early breast cancer. Nature Publishing Group UK 2019-02-04 /pmc/articles/PMC6361949/ /pubmed/30718646 http://dx.doi.org/10.1038/s41598-018-37664-7 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Kovács, Tünde Mikó, Edit Vida, András Sebő, Éva Toth, Judit Csonka, Tamás Boratkó, Anita Ujlaki, Gyula Lente, Gréta Kovács, Patrik Tóth, Dezső Árkosy, Péter Kiss, Borbála Méhes, Gábor Goedert, James J. Bai, Péter Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors |
title | Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors |
title_full | Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors |
title_fullStr | Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors |
title_full_unstemmed | Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors |
title_short | Cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors |
title_sort | cadaverine, a metabolite of the microbiome, reduces breast cancer aggressiveness through trace amino acid receptors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361949/ https://www.ncbi.nlm.nih.gov/pubmed/30718646 http://dx.doi.org/10.1038/s41598-018-37664-7 |
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