3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish

3-ketodihydrosphingosine reductase (KDSR) is the key enzyme in the de novo sphingolipid synthesis. We identified a novel missense kdsr(I105R) mutation in zebrafish that led to a loss of function, and resulted in progression of hepatomegaly to steatosis, then hepatic injury phenotype. Lipidomics anal...

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Detalles Bibliográficos
Autores principales: Park, Ki-Hoon, Ye, Zhi-wei, Zhang, Jie, Hammad, Samar M., Townsend, Danyelle M., Rockey, Don C., Kim, Seok-Hyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361991/
https://www.ncbi.nlm.nih.gov/pubmed/30718751
http://dx.doi.org/10.1038/s41598-018-37946-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361991/
https://www.ncbi.nlm.nih.gov/pubmed/30718751
http://dx.doi.org/10.1038/s41598-018-37946-0

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