The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedi...

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Autores principales: Szatkiewicz, Jin, Crowley, James J., Adolfsson, Annelie Nordin, Åberg, Karolina A., Alaerts, Maaike, Genovese, Giulio, McCarroll, Steven, Del-Favero, Jurgen, Adolfsson, Rolf, Sullivan, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362018/
https://www.ncbi.nlm.nih.gov/pubmed/30718465
http://dx.doi.org/10.1038/s41398-019-0414-9
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author Szatkiewicz, Jin
Crowley, James J.
Adolfsson, Annelie Nordin
Åberg, Karolina A.
Alaerts, Maaike
Genovese, Giulio
McCarroll, Steven
Del-Favero, Jurgen
Adolfsson, Rolf
Sullivan, Patrick F.
author_facet Szatkiewicz, Jin
Crowley, James J.
Adolfsson, Annelie Nordin
Åberg, Karolina A.
Alaerts, Maaike
Genovese, Giulio
McCarroll, Steven
Del-Favero, Jurgen
Adolfsson, Rolf
Sullivan, Patrick F.
author_sort Szatkiewicz, Jin
collection PubMed
description We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.
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spelling pubmed-63620182019-02-06 The genomics of major psychiatric disorders in a large pedigree from Northern Sweden Szatkiewicz, Jin Crowley, James J. Adolfsson, Annelie Nordin Åberg, Karolina A. Alaerts, Maaike Genovese, Giulio McCarroll, Steven Del-Favero, Jurgen Adolfsson, Rolf Sullivan, Patrick F. Transl Psychiatry Article We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls. Nature Publishing Group UK 2019-02-04 /pmc/articles/PMC6362018/ /pubmed/30718465 http://dx.doi.org/10.1038/s41398-019-0414-9 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Szatkiewicz, Jin
Crowley, James J.
Adolfsson, Annelie Nordin
Åberg, Karolina A.
Alaerts, Maaike
Genovese, Giulio
McCarroll, Steven
Del-Favero, Jurgen
Adolfsson, Rolf
Sullivan, Patrick F.
The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_full The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_fullStr The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_full_unstemmed The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_short The genomics of major psychiatric disorders in a large pedigree from Northern Sweden
title_sort genomics of major psychiatric disorders in a large pedigree from northern sweden
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362018/
https://www.ncbi.nlm.nih.gov/pubmed/30718465
http://dx.doi.org/10.1038/s41398-019-0414-9
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