Methylglyoxal down-regulates the expression of cell cycle associated genes and activates the p53 pathway in human umbilical vein endothelial cells

Although methylglyoxal (MGO) has emerged as key mediator of diabetic microvascular complications, the influence of MGO on the vascular transcriptome has not thoroughly been assessed. Since diabetes is associated with low grade inflammation causing sustained nuclear factor-kappa B (NF-κB) activation,...

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Detalles Bibliográficos
Autores principales: Braun, Jana D., Pastene, Diego O., Breedijk, Annette, Rodriguez, Angelica, Hofmann, Björn B., Sticht, Carsten, von Ochsenstein, Elke, Allgayer, Heike, van den Born, Jacob, Bakker, Stephan, Hauske, Sibylle J., Krämer, Bernhard K., Yard, Benito A., Albrecht, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362029/
https://www.ncbi.nlm.nih.gov/pubmed/30718683
http://dx.doi.org/10.1038/s41598-018-37937-1

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