SMARCA4 loss is synthetic lethal with CDK4/6 inhibition in non-small cell lung cancer

Tumor suppressor SMARCA4 (BRG1), a key SWI/SNF chromatin remodeling gene, is frequently inactivated in cancers and is not directly druggable. We recently uncovered that SMARCA4 loss in an ovarian cancer subtype causes cyclin D1 deficiency leading to susceptibility to CDK4/6 inhibition. Here, we show...

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Detalles Bibliográficos
Autores principales: Xue, Yibo, Meehan, Brian, Fu, Zheng, Wang, Xue Qing D., Fiset, Pierre Olivier, Rieker, Ralf, Levins, Cameron, Kong, Tim, Zhu, Xianbing, Morin, Geneviève, Skerritt, Lashanda, Herpel, Esther, Venneti, Sriram, Martinez, Daniel, Judkins, Alexander R., Jung, Sungmi, Camilleri-Broet, Sophie, Gonzalez, Anne V., Guiot, Marie-Christine, Lockwood, William W., Spicer, Jonathan D., Agaimy, Abbas, Pastor, William A., Dostie, Josée, Rak, Janusz, Foulkes, William D., Huang, Sidong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362083/
https://www.ncbi.nlm.nih.gov/pubmed/30718506
http://dx.doi.org/10.1038/s41467-019-08380-1

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