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Patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats

Baroreflex dysfunction is a diffuse chronic condition that is expected to be followed by a profound loss of organization of BP and HR variability. Nevertheless, long-term effects of baroreflex withdrawal are still debated. Aim of our work was to study BP and HR changes long term after sino-aortic de...

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Autores principales: Radaelli, Alberto, Mancia, Giuseppe, De Carlini, Caterina, Soriano, Francesco, Castiglioni, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362124/
https://www.ncbi.nlm.nih.gov/pubmed/30718760
http://dx.doi.org/10.1038/s41598-018-37970-0
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author Radaelli, Alberto
Mancia, Giuseppe
De Carlini, Caterina
Soriano, Francesco
Castiglioni, Paolo
author_facet Radaelli, Alberto
Mancia, Giuseppe
De Carlini, Caterina
Soriano, Francesco
Castiglioni, Paolo
author_sort Radaelli, Alberto
collection PubMed
description Baroreflex dysfunction is a diffuse chronic condition that is expected to be followed by a profound loss of organization of BP and HR variability. Nevertheless, long-term effects of baroreflex withdrawal are still debated. Aim of our work was to study BP and HR changes long term after sino-aortic denervation (SAD). Inter-beat-interval (IBI) and intra-arterial BP were recorded beat-by-beat in 43 Wistar-Kyoto rats (Controls, n = 33; SAD rats, n = 10). Power spectra were calculated in controls and in SAD rats within three days and at seven months from denervation. Compared to controls, chronic SAD rats showed 1) similar mean BP (control vs SAD: 95 ± 16 vs 87 ± 22 mmHg) and IBI (171 ± 22 vs 181 ± 15 ms) values, 2) dramatically higher values of BP variance (12 ± 2 vs 64 ± 2 mmHg(2), p < 0.01) and of ultra- (ULF) and very-low-frequency (VLF) BP oscillations, 3) dramatically higher values of IBI variability (24 ± 2 vs 71 ± 4 ms(2), p < 0.01) and of ULF-IBI oscillations that were synchronized with BP oscillations. Chronic SAD rats reveal a marked change in the pattern of cardiovascular variability characterized by the appearance of synchronized slower oscillations of BP and HR. The cardiovascular system, therefore, retains a high level of organization despite the absence of a reflex control mechanism.
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spelling pubmed-63621242019-02-06 Patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats Radaelli, Alberto Mancia, Giuseppe De Carlini, Caterina Soriano, Francesco Castiglioni, Paolo Sci Rep Article Baroreflex dysfunction is a diffuse chronic condition that is expected to be followed by a profound loss of organization of BP and HR variability. Nevertheless, long-term effects of baroreflex withdrawal are still debated. Aim of our work was to study BP and HR changes long term after sino-aortic denervation (SAD). Inter-beat-interval (IBI) and intra-arterial BP were recorded beat-by-beat in 43 Wistar-Kyoto rats (Controls, n = 33; SAD rats, n = 10). Power spectra were calculated in controls and in SAD rats within three days and at seven months from denervation. Compared to controls, chronic SAD rats showed 1) similar mean BP (control vs SAD: 95 ± 16 vs 87 ± 22 mmHg) and IBI (171 ± 22 vs 181 ± 15 ms) values, 2) dramatically higher values of BP variance (12 ± 2 vs 64 ± 2 mmHg(2), p < 0.01) and of ultra- (ULF) and very-low-frequency (VLF) BP oscillations, 3) dramatically higher values of IBI variability (24 ± 2 vs 71 ± 4 ms(2), p < 0.01) and of ULF-IBI oscillations that were synchronized with BP oscillations. Chronic SAD rats reveal a marked change in the pattern of cardiovascular variability characterized by the appearance of synchronized slower oscillations of BP and HR. The cardiovascular system, therefore, retains a high level of organization despite the absence of a reflex control mechanism. Nature Publishing Group UK 2019-02-04 /pmc/articles/PMC6362124/ /pubmed/30718760 http://dx.doi.org/10.1038/s41598-018-37970-0 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Radaelli, Alberto
Mancia, Giuseppe
De Carlini, Caterina
Soriano, Francesco
Castiglioni, Paolo
Patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats
title Patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats
title_full Patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats
title_fullStr Patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats
title_full_unstemmed Patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats
title_short Patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats
title_sort patterns of cardiovascular variability after long-term sino-aortic denervation in unanesthetized adult rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362124/
https://www.ncbi.nlm.nih.gov/pubmed/30718760
http://dx.doi.org/10.1038/s41598-018-37970-0
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