Cul4 E3 ubiquitin ligase regulates ovarian cancer drug resistance by targeting the antiapoptotic protein BIRC3

CRL4, a well-defined E3 ligase, has been reported to be upregulated and is proposed to be a potential drug target in ovarian cancers. However, the biological functions of CRL4 and the underlying mechanism regulating cancer chemoresistance are still largely elusive. Here, we show that CRL4 is conside...

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Detalles Bibliográficos
Autores principales: Hu, Xiaoyan, Meng, Yang, Xu, Lian, Qiu, Lei, Wei, Mingtian, Su, Dan, Qi, Xu, Wang, Ziqiang, Yang, Shengyong, Liu, Cong, Han, Junhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362125/
https://www.ncbi.nlm.nih.gov/pubmed/30718461
http://dx.doi.org/10.1038/s41419-018-1200-y

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