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Determination of basal phosphodiesterase activity in mouse rod photoreceptors with cGMP clamp
Light regulates cGMP concentration in the photoreceptor cytoplasm by activating phosphodiesterase (PDE) molecules through a G-protein signalling cascade. Spontaneous PDE activity is present in rod outer segments even in darkness. This basal PDE activity (β(dark)) has not been determined in wild type...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362171/ https://www.ncbi.nlm.nih.gov/pubmed/30718640 http://dx.doi.org/10.1038/s41598-018-37661-w |