Ligand-induced conformational switch in an artificial bidomain protein scaffold

Artificial proteins binding any predefined “target” protein can now be efficiently generated using combinatorial libraries based on robust protein scaffolds. αRep is such a family of artificial proteins, based on an α-solenoid protein repeat scaffold. The low aggregation propensity of the specific “...

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Detalles Bibliográficos
Autores principales: Léger, Corentin, Di Meo, Thibault, Aumont-Nicaise, Magali, Velours, Christophe, Durand, Dominique, Li de la Sierra-Gallay, Ines, van Tilbeurgh, Herman, Hildebrandt, Niko, Desmadril, Michel, Urvoas, Agathe, Valerio-Lepiniec, Marie, Minard, Philippe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362204/
https://www.ncbi.nlm.nih.gov/pubmed/30718544
http://dx.doi.org/10.1038/s41598-018-37256-5

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