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Molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds
Trichobilharzia species are parasitic flatworms (called schistosomes or flukes) that cause important diseases in birds and humans, but very little is known about their molecular biology. Here, using a transcriptomics-bioinformatics-based approach, we explored molecular aspects pertaining to the nutr...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362228/ https://www.ncbi.nlm.nih.gov/pubmed/30718911 http://dx.doi.org/10.1038/s41598-018-37669-2 |
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author | Leontovyč, Roman Young, Neil D. Korhonen, Pasi K. Hall, Ross S. Bulantová, Jana Jeřábková, Veronika Kašný, Martin Gasser, Robin B. Horák, Petr |
author_facet | Leontovyč, Roman Young, Neil D. Korhonen, Pasi K. Hall, Ross S. Bulantová, Jana Jeřábková, Veronika Kašný, Martin Gasser, Robin B. Horák, Petr |
author_sort | Leontovyč, Roman |
collection | PubMed |
description | Trichobilharzia species are parasitic flatworms (called schistosomes or flukes) that cause important diseases in birds and humans, but very little is known about their molecular biology. Here, using a transcriptomics-bioinformatics-based approach, we explored molecular aspects pertaining to the nutritional requirements of Trichobilharzia szidati (‘visceral fluke’) and T. regenti (‘neurotropic fluke’) in their avian host. We studied the larvae of each species before they enter (cercariae) and as they migrate (schistosomules) through distinct tissues in their avian (duck) host. Cercariae of both species were enriched for pathways or molecules associated predominantly with carbohydrate metabolism, oxidative phosphorylation and translation of proteins linked to ribosome biogenesis, exosome production and/or lipid biogenesis. Schistosomules of both species were enriched for pathways or molecules associated with processes including signal transduction, cell turnover and motility, DNA replication and repair, molecular transport and/or catabolism. Comparative informatic analyses identified molecular repertoires (within, e.g., peptidases and secretory proteins) in schistosomules that can broadly degrade macromolecules in both T. szidati and T. regenti, and others that are tailored to each species to selectively acquire nutrients from particular tissues through which it migrates. Thus, this study provides molecular evidence for distinct modes of nutrient acquisition between the visceral and neurotropic flukes of birds. |
format | Online Article Text |
id | pubmed-6362228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-63622282019-02-06 Molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds Leontovyč, Roman Young, Neil D. Korhonen, Pasi K. Hall, Ross S. Bulantová, Jana Jeřábková, Veronika Kašný, Martin Gasser, Robin B. Horák, Petr Sci Rep Article Trichobilharzia species are parasitic flatworms (called schistosomes or flukes) that cause important diseases in birds and humans, but very little is known about their molecular biology. Here, using a transcriptomics-bioinformatics-based approach, we explored molecular aspects pertaining to the nutritional requirements of Trichobilharzia szidati (‘visceral fluke’) and T. regenti (‘neurotropic fluke’) in their avian host. We studied the larvae of each species before they enter (cercariae) and as they migrate (schistosomules) through distinct tissues in their avian (duck) host. Cercariae of both species were enriched for pathways or molecules associated predominantly with carbohydrate metabolism, oxidative phosphorylation and translation of proteins linked to ribosome biogenesis, exosome production and/or lipid biogenesis. Schistosomules of both species were enriched for pathways or molecules associated with processes including signal transduction, cell turnover and motility, DNA replication and repair, molecular transport and/or catabolism. Comparative informatic analyses identified molecular repertoires (within, e.g., peptidases and secretory proteins) in schistosomules that can broadly degrade macromolecules in both T. szidati and T. regenti, and others that are tailored to each species to selectively acquire nutrients from particular tissues through which it migrates. Thus, this study provides molecular evidence for distinct modes of nutrient acquisition between the visceral and neurotropic flukes of birds. Nature Publishing Group UK 2019-02-04 /pmc/articles/PMC6362228/ /pubmed/30718911 http://dx.doi.org/10.1038/s41598-018-37669-2 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Leontovyč, Roman Young, Neil D. Korhonen, Pasi K. Hall, Ross S. Bulantová, Jana Jeřábková, Veronika Kašný, Martin Gasser, Robin B. Horák, Petr Molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds |
title | Molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds |
title_full | Molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds |
title_fullStr | Molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds |
title_full_unstemmed | Molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds |
title_short | Molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds |
title_sort | molecular evidence for distinct modes of nutrient acquisition between visceral and neurotropic schistosomes of birds |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362228/ https://www.ncbi.nlm.nih.gov/pubmed/30718911 http://dx.doi.org/10.1038/s41598-018-37669-2 |
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