Both a Unique Motif at the C Terminus and an N-Terminal HEAT Repeat Contribute to G-Quadruplex Binding and Origin Regulation by the Rif1 Protein

Rif1 is a key factor for spatiotemporal regulation of DNA replication. Rif1 suppresses origin firing in the mid-late replication domains by generating replication-suppressive chromatin architecture and by recruiting a protein phosphatase. In fission yeast, the function of Hsk1, a kinase important fo...

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Detalles Bibliográficos
Autores principales: Kobayashi, Shunsuke, Fukatsu, Rino, Kanoh, Yutaka, Kakusho, Naoko, Matsumoto, Seiji, Chaen, Shigeru, Masai, Hisao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362314/
https://www.ncbi.nlm.nih.gov/pubmed/30510058
http://dx.doi.org/10.1128/MCB.00364-18

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