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Association of mononucleotide polymorphisms of angiotensinogen gene at promoter region with antihypertensive response to angiotensin receptor blockers in hypertensive Chinese
INTRODUCTION: This study aimed to investigate whether mononucleotide polymorphisms of the angiotensinogen gene at promoter were associated with the blood-pressure-lowering response to telmisartan treatment. MATERIALS AND METHODS: After a two-week single-blind placebo run-in period, 148 patients with...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362516/ https://www.ncbi.nlm.nih.gov/pubmed/30798697 http://dx.doi.org/10.1177/1470320319827205 |
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author | Gong, Hong-Tao Mu, Li-Ying Zhang, Tong Xu, Xiu-Ying Du, Feng-He |
author_facet | Gong, Hong-Tao Mu, Li-Ying Zhang, Tong Xu, Xiu-Ying Du, Feng-He |
author_sort | Gong, Hong-Tao |
collection | PubMed |
description | INTRODUCTION: This study aimed to investigate whether mononucleotide polymorphisms of the angiotensinogen gene at promoter were associated with the blood-pressure-lowering response to telmisartan treatment. MATERIALS AND METHODS: After a two-week single-blind placebo run-in period, 148 patients with mild-to-moderate primary hypertension received monotherapy with 80 mg/day of telmisartan and then were followed up for eight weeks. The -6A/G and -20A/C polymorphisms of the angiotensinogen gene at promoter were determined through polymerase chain reaction and restriction fragment length polymorphsim analysis. The relationship between these polymorphisms and changes in blood pressure was observed and evaluated after eight weeks of treatment. RESULTS: There were no significant differences between -6A/G, -20A/C polymorphisms of the angiotensinogen gene and blood pressure reductions after treatment, p>0.05. CONCLUSION: It is suggested that angiotensinogen-6 A/G and angiotensinogen-20 A/C polymorphisms were not associated with the antihypertensive response to telmisartan treatment in Chinese patients with hypertension. |
format | Online Article Text |
id | pubmed-6362516 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-63625162019-02-15 Association of mononucleotide polymorphisms of angiotensinogen gene at promoter region with antihypertensive response to angiotensin receptor blockers in hypertensive Chinese Gong, Hong-Tao Mu, Li-Ying Zhang, Tong Xu, Xiu-Ying Du, Feng-He J Renin Angiotensin Aldosterone Syst Original Article INTRODUCTION: This study aimed to investigate whether mononucleotide polymorphisms of the angiotensinogen gene at promoter were associated with the blood-pressure-lowering response to telmisartan treatment. MATERIALS AND METHODS: After a two-week single-blind placebo run-in period, 148 patients with mild-to-moderate primary hypertension received monotherapy with 80 mg/day of telmisartan and then were followed up for eight weeks. The -6A/G and -20A/C polymorphisms of the angiotensinogen gene at promoter were determined through polymerase chain reaction and restriction fragment length polymorphsim analysis. The relationship between these polymorphisms and changes in blood pressure was observed and evaluated after eight weeks of treatment. RESULTS: There were no significant differences between -6A/G, -20A/C polymorphisms of the angiotensinogen gene and blood pressure reductions after treatment, p>0.05. CONCLUSION: It is suggested that angiotensinogen-6 A/G and angiotensinogen-20 A/C polymorphisms were not associated with the antihypertensive response to telmisartan treatment in Chinese patients with hypertension. SAGE Publications 2019-02-03 /pmc/articles/PMC6362516/ /pubmed/30798697 http://dx.doi.org/10.1177/1470320319827205 Text en © The Author(s) 2019 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Article Gong, Hong-Tao Mu, Li-Ying Zhang, Tong Xu, Xiu-Ying Du, Feng-He Association of mononucleotide polymorphisms of angiotensinogen gene at promoter region with antihypertensive response to angiotensin receptor blockers in hypertensive Chinese |
title | Association of mononucleotide polymorphisms of angiotensinogen gene
at promoter region with antihypertensive response to angiotensin receptor
blockers in hypertensive Chinese |
title_full | Association of mononucleotide polymorphisms of angiotensinogen gene
at promoter region with antihypertensive response to angiotensin receptor
blockers in hypertensive Chinese |
title_fullStr | Association of mononucleotide polymorphisms of angiotensinogen gene
at promoter region with antihypertensive response to angiotensin receptor
blockers in hypertensive Chinese |
title_full_unstemmed | Association of mononucleotide polymorphisms of angiotensinogen gene
at promoter region with antihypertensive response to angiotensin receptor
blockers in hypertensive Chinese |
title_short | Association of mononucleotide polymorphisms of angiotensinogen gene
at promoter region with antihypertensive response to angiotensin receptor
blockers in hypertensive Chinese |
title_sort | association of mononucleotide polymorphisms of angiotensinogen gene
at promoter region with antihypertensive response to angiotensin receptor
blockers in hypertensive chinese |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362516/ https://www.ncbi.nlm.nih.gov/pubmed/30798697 http://dx.doi.org/10.1177/1470320319827205 |
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