Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects

BACKGROUND: CRISPR-Cas9 genome editing is widely used to study gene function, from basic biology to biomedical research. Structural rearrangements are a ubiquitous feature of cancer cells and their impact on the functional consequences of CRISPR-Cas9 gene-editing has not yet been assessed. RESULTS:...

Descripción completa

Detalles Bibliográficos
Autores principales: Gonçalves, Emanuel, Behan, Fiona M., Louzada, Sandra, Arnol, Damien, Stronach, Euan A., Yang, Fengtang, Yusa, Kosuke, Stegle, Oliver, Iorio, Francesco, Garnett, Mathew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362594/
https://www.ncbi.nlm.nih.gov/pubmed/30722791
http://dx.doi.org/10.1186/s13059-019-1637-z

Ejemplares similares

Ejemplares similares