High-content imaging analyses of γH2AX-foci and micronuclei in TK6 cells elucidated genotoxicity of chemicals and their clastogenic/aneugenic mode of action

BACKGROUND: The in vitro micronucleus (MN) test is an important component of a genotoxicity test battery that evaluates chemicals. Although the standard method of manually scoring micronucleated (MNed) cells by microscope is a reliable and standard method, it is laborious and time-consuming. A high-...

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Detalles Bibliográficos
Autores principales: Takeiri, Akira, Matsuzaki, Kaori, Motoyama, Shigeki, Yano, Mariko, Harada, Asako, Katoh, Chiaki, Tanaka, Kenji, Mishima, Masayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362597/
https://www.ncbi.nlm.nih.gov/pubmed/30766621
http://dx.doi.org/10.1186/s41021-019-0117-8

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