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Crystal structure of 7′-(4-chloro­phen­yl)-2′′-(4-meth­oxy­phen­yl)-7′,7a’,7′′,8′′-tetra­hydro-1′H,3′H,5′′H-di­spiro­[indoline-3,5′-pyrrolo­[1,2-c]thia­zole-6′,6′′-quinoline]-2,5′′-dione and an unknown solvent

The asymmetric unit of the title compound, C(34)H(28)ClN(3)O(3)S, contains two independent mol­ecules (A and B). They differ essentially in the orientation of the 4-meth­oxy­phenyl ring with respect to the pyridine ring of the quinoline moiety; this dihedral angle is 37.01 (18)° in mol­ecule A but o...

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Detalles Bibliográficos
Autores principales: Vishnupriya, R., Venkateshan, M., Suresh, J., Sumesh, R. V., Kumar, R. Ranjith, Lakshman, P. L. Nilantha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362668/
https://www.ncbi.nlm.nih.gov/pubmed/30800449
http://dx.doi.org/10.1107/S2056989019000112
Descripción
Sumario:The asymmetric unit of the title compound, C(34)H(28)ClN(3)O(3)S, contains two independent mol­ecules (A and B). They differ essentially in the orientation of the 4-meth­oxy­phenyl ring with respect to the pyridine ring of the quinoline moiety; this dihedral angle is 37.01 (18)° in mol­ecule A but only 7.06 (17)° in mol­ecule B. In both mol­ecules, the cyclo­hexa­none ring of the iso­quinoline unit has a half-chair conformation. In the pyrrolo­thia­zole ring system, the pyrrolo ring in mol­ecule A has a twisted conformation on the N—C fused bond and an envelope conformation in mol­ecule B with the N atom as the flap. The thia­zole rings of both mol­ecules have twisted conformations on the N—C fused bond. In the crystal, the A mol­ecules are linked by pairs of N—H⋯O hydrogen bonds, forming inversion dimers with an R (2) (2)(8) ring motif. These dimers are linked to the B mol­ecules by an N—H⋯N hydrogen bond and a series of C—H⋯O hydrogen bonds, forming layers lying parallel to the (101) plane. The layers are linked by C—H⋯π inter­actions and offset π–π inter­actions [inter­centroid distance = 3.427 (1) Å], forming a supra­molecular framework. The contribution to the scattering from a region of highly disordered solvent mol­ecules was removed with the SQUEEZE routine in PLATON [Spek (2015 ▸). Acta Cryst. C71, 9–18]. The solvent formula mass and unit-cell characteristics were not taken into account during refinement.