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The crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2H,6′H,8′H-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one

In the title compounds, C(32)H(25)ClN(2)O(4) (I) and C(33)H(28)N(2)O(5) (II), the six-membered pyran and piperidine rings adopt envelope and chair conformations, respectively. The five-membered pyrrolidine rings adopt twist conformations. Compound (II) crystallizes with two independent mol­ecules (A...

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Detalles Bibliográficos
Autores principales: Syed Abuthahir, S., NizamMohideen, M., Viswanathan, V., Velmurugan, D., Nagasivarao, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362674/
https://www.ncbi.nlm.nih.gov/pubmed/30800454
http://dx.doi.org/10.1107/S2056989019000422
Descripción
Sumario:In the title compounds, C(32)H(25)ClN(2)O(4) (I) and C(33)H(28)N(2)O(5) (II), the six-membered pyran and piperidine rings adopt envelope and chair conformations, respectively. The five-membered pyrrolidine rings adopt twist conformations. Compound (II) crystallizes with two independent mol­ecules (A and B) in the asymmetric unit. In all three mol­ecules there is a C—H⋯O intra­molecular hydrogen bond present enclosing an S(7) ring motif. In (I), both oxygen atoms of the nitro group are disordered, while in (II) the meth­oxy­benzene group is disordered in mol­ecule B. The geometries were regularized by soft restraints. In the crystal of (I), mol­ecules are linked by C—H⋯O hydrogen bonds, forming chains along [010]. The chains are linked by C—H⋯Cl hydrogen bonds, forming layers parallel to (10[Image: see text]). Within the layer there are C—H⋯π inter­actions present. In the crystal of (II), the A and B mol­ecules are linked via C—H⋯O hydrogen bonds, forming a square four-membered A–B–A–B unit. These units are linked by a number of C—H⋯π inter­actions, forming a three-dimensional supra­molecular structure.