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The crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2H,6′H,8′H-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one

In the title compounds, C(32)H(25)ClN(2)O(4) (I) and C(33)H(28)N(2)O(5) (II), the six-membered pyran and piperidine rings adopt envelope and chair conformations, respectively. The five-membered pyrrolidine rings adopt twist conformations. Compound (II) crystallizes with two independent mol­ecules (A...

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Autores principales: Syed Abuthahir, S., NizamMohideen, M., Viswanathan, V., Velmurugan, D., Nagasivarao, J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362674/
https://www.ncbi.nlm.nih.gov/pubmed/30800454
http://dx.doi.org/10.1107/S2056989019000422
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author Syed Abuthahir, S.
NizamMohideen, M.
Viswanathan, V.
Velmurugan, D.
Nagasivarao, J.
author_facet Syed Abuthahir, S.
NizamMohideen, M.
Viswanathan, V.
Velmurugan, D.
Nagasivarao, J.
author_sort Syed Abuthahir, S.
collection PubMed
description In the title compounds, C(32)H(25)ClN(2)O(4) (I) and C(33)H(28)N(2)O(5) (II), the six-membered pyran and piperidine rings adopt envelope and chair conformations, respectively. The five-membered pyrrolidine rings adopt twist conformations. Compound (II) crystallizes with two independent mol­ecules (A and B) in the asymmetric unit. In all three mol­ecules there is a C—H⋯O intra­molecular hydrogen bond present enclosing an S(7) ring motif. In (I), both oxygen atoms of the nitro group are disordered, while in (II) the meth­oxy­benzene group is disordered in mol­ecule B. The geometries were regularized by soft restraints. In the crystal of (I), mol­ecules are linked by C—H⋯O hydrogen bonds, forming chains along [010]. The chains are linked by C—H⋯Cl hydrogen bonds, forming layers parallel to (10[Image: see text]). Within the layer there are C—H⋯π inter­actions present. In the crystal of (II), the A and B mol­ecules are linked via C—H⋯O hydrogen bonds, forming a square four-membered A–B–A–B unit. These units are linked by a number of C—H⋯π inter­actions, forming a three-dimensional supra­molecular structure.
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spelling pubmed-63626742019-02-22 The crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2H,6′H,8′H-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one Syed Abuthahir, S. NizamMohideen, M. Viswanathan, V. Velmurugan, D. Nagasivarao, J. Acta Crystallogr E Crystallogr Commun Research Communications In the title compounds, C(32)H(25)ClN(2)O(4) (I) and C(33)H(28)N(2)O(5) (II), the six-membered pyran and piperidine rings adopt envelope and chair conformations, respectively. The five-membered pyrrolidine rings adopt twist conformations. Compound (II) crystallizes with two independent mol­ecules (A and B) in the asymmetric unit. In all three mol­ecules there is a C—H⋯O intra­molecular hydrogen bond present enclosing an S(7) ring motif. In (I), both oxygen atoms of the nitro group are disordered, while in (II) the meth­oxy­benzene group is disordered in mol­ecule B. The geometries were regularized by soft restraints. In the crystal of (I), mol­ecules are linked by C—H⋯O hydrogen bonds, forming chains along [010]. The chains are linked by C—H⋯Cl hydrogen bonds, forming layers parallel to (10[Image: see text]). Within the layer there are C—H⋯π inter­actions present. In the crystal of (II), the A and B mol­ecules are linked via C—H⋯O hydrogen bonds, forming a square four-membered A–B–A–B unit. These units are linked by a number of C—H⋯π inter­actions, forming a three-dimensional supra­molecular structure. International Union of Crystallography 2019-01-15 /pmc/articles/PMC6362674/ /pubmed/30800454 http://dx.doi.org/10.1107/S2056989019000422 Text en © Syed Abuthahir et al. 2019 http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.http://creativecommons.org/licenses/by/4.0/
spellingShingle Research Communications
Syed Abuthahir, S.
NizamMohideen, M.
Viswanathan, V.
Velmurugan, D.
Nagasivarao, J.
The crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2H,6′H,8′H-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one
title The crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2H,6′H,8′H-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one
title_full The crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2H,6′H,8′H-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one
title_fullStr The crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2H,6′H,8′H-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one
title_full_unstemmed The crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2H,6′H,8′H-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one
title_short The crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2H,6′H,8′H-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one
title_sort crystal structures of 6′-(4-chloro­phen­yl)- and 6′-(4-meth­oxy­phen­yl)-6a′-nitro-6a′,6b′,7′,9′,10′,12a′-hexa­hydro-2h,6′h,8′h-spiro­[ace­naphthyl­ene-1,12′-chromeno[3,4-a]indolizin]-2-one
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362674/
https://www.ncbi.nlm.nih.gov/pubmed/30800454
http://dx.doi.org/10.1107/S2056989019000422
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