Cargando…

Comorbidities in Lichen Planus: A Case–control Study in Indian Patients

BACKGROUND: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, meta...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, S. Ashwin, Krishnam Raju, P. V., Gopal, K. V. T., Rao, T. Narayana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362740/
https://www.ncbi.nlm.nih.gov/pubmed/30775296
http://dx.doi.org/10.4103/idoj.IDOJ_48_18
_version_ 1783392989382443008
author Kumar, S. Ashwin
Krishnam Raju, P. V.
Gopal, K. V. T.
Rao, T. Narayana
author_facet Kumar, S. Ashwin
Krishnam Raju, P. V.
Gopal, K. V. T.
Rao, T. Narayana
author_sort Kumar, S. Ashwin
collection PubMed
description BACKGROUND: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, metabolic syndrome, thyroid dysfunction, and hepatitis C virus (HCV) infection. MATERIALS AND METHODS: The study included 75 patients with clinical diagnosis of LP and 75 age- and sex-matched controls. After taking complete history, general examination and thorough dermatological examination were performed in all cases. Fasting serum samples were taken from all cases and controls and assayed for fasting plasma glucose, lipid profile, T3, T4, and thyroid-stimulating hormone levels, and anti-HCVantibodies. Metabolic syndrome was diagnosed according to 2005 revised National Cholesterol Education Programme's Adult Treatment Panel III. Two-sample Student's t-test was used for statistical analysis. RESULTS: Increased triglyceride levels were seen in 26 cases (34.67%) compared with 14 controls (14%), which was significant (P = 0.024). Statistically significant increased prevalence of increasedlow-density lipoprotein levels (P = 0.027), low high-density lipoprotein levels (P = 0.0189), and diabetes mellitus (P = 0.0217) was also observed in LP. Metabolic syndrome (P = 0.656) and hypothyroidism (P = 0.117) were not significantly associated with LP. Strong association was observed between oral LP and hypothyroidism. All patients screened for anti-HCV antibodies were found to be negative. CONCLUSION: There is a clear associationof LP with dyslipidemia and diabetes mellitus. Screening for dyslipidemia and diabetes mellitus in all patients of LP will help in early detection, initiation of treatment, and prevent long-term morbidity.
format Online
Article
Text
id pubmed-6362740
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-63627402019-02-17 Comorbidities in Lichen Planus: A Case–control Study in Indian Patients Kumar, S. Ashwin Krishnam Raju, P. V. Gopal, K. V. T. Rao, T. Narayana Indian Dermatol Online J Original Article BACKGROUND: Many previous studies have observed an association of lichen planus (LP) with one or two comorbidities such as diabetes mellitus and thyroid dysfunction. This study was undertaken to determine the association of LP with common comorbidities including diabetes mellitus, dyslipidemia, metabolic syndrome, thyroid dysfunction, and hepatitis C virus (HCV) infection. MATERIALS AND METHODS: The study included 75 patients with clinical diagnosis of LP and 75 age- and sex-matched controls. After taking complete history, general examination and thorough dermatological examination were performed in all cases. Fasting serum samples were taken from all cases and controls and assayed for fasting plasma glucose, lipid profile, T3, T4, and thyroid-stimulating hormone levels, and anti-HCVantibodies. Metabolic syndrome was diagnosed according to 2005 revised National Cholesterol Education Programme's Adult Treatment Panel III. Two-sample Student's t-test was used for statistical analysis. RESULTS: Increased triglyceride levels were seen in 26 cases (34.67%) compared with 14 controls (14%), which was significant (P = 0.024). Statistically significant increased prevalence of increasedlow-density lipoprotein levels (P = 0.027), low high-density lipoprotein levels (P = 0.0189), and diabetes mellitus (P = 0.0217) was also observed in LP. Metabolic syndrome (P = 0.656) and hypothyroidism (P = 0.117) were not significantly associated with LP. Strong association was observed between oral LP and hypothyroidism. All patients screened for anti-HCV antibodies were found to be negative. CONCLUSION: There is a clear associationof LP with dyslipidemia and diabetes mellitus. Screening for dyslipidemia and diabetes mellitus in all patients of LP will help in early detection, initiation of treatment, and prevent long-term morbidity. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6362740/ /pubmed/30775296 http://dx.doi.org/10.4103/idoj.IDOJ_48_18 Text en Copyright: © 2019 Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Kumar, S. Ashwin
Krishnam Raju, P. V.
Gopal, K. V. T.
Rao, T. Narayana
Comorbidities in Lichen Planus: A Case–control Study in Indian Patients
title Comorbidities in Lichen Planus: A Case–control Study in Indian Patients
title_full Comorbidities in Lichen Planus: A Case–control Study in Indian Patients
title_fullStr Comorbidities in Lichen Planus: A Case–control Study in Indian Patients
title_full_unstemmed Comorbidities in Lichen Planus: A Case–control Study in Indian Patients
title_short Comorbidities in Lichen Planus: A Case–control Study in Indian Patients
title_sort comorbidities in lichen planus: a case–control study in indian patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362740/
https://www.ncbi.nlm.nih.gov/pubmed/30775296
http://dx.doi.org/10.4103/idoj.IDOJ_48_18
work_keys_str_mv AT kumarsashwin comorbiditiesinlichenplanusacasecontrolstudyinindianpatients
AT krishnamrajupv comorbiditiesinlichenplanusacasecontrolstudyinindianpatients
AT gopalkvt comorbiditiesinlichenplanusacasecontrolstudyinindianpatients
AT raotnarayana comorbiditiesinlichenplanusacasecontrolstudyinindianpatients