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Evaluation of Association of Vitamin D in Alopecia Areata: A Case–control Study of 100 Patients in a Tertiary Rural Hospital of Southern India

BACKGROUND: Alopecia areata is a common autoimmune disorder which is characterized by non-scarring hair loss. Vitamin D plays an important role in immune regulation, cell growth, differentiation, and maintenance of hair cycle. AIMS AND OBJECTIVES: (1) To evaluate serum vitamin D levels in alopecia a...

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Autores principales: Siddappa, Harsha, Kumar, Y. Hari Kishan, Vivekananda, N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362755/
https://www.ncbi.nlm.nih.gov/pubmed/30775298
http://dx.doi.org/10.4103/idoj.IDOJ_84_18
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author Siddappa, Harsha
Kumar, Y. Hari Kishan
Vivekananda, N
author_facet Siddappa, Harsha
Kumar, Y. Hari Kishan
Vivekananda, N
author_sort Siddappa, Harsha
collection PubMed
description BACKGROUND: Alopecia areata is a common autoimmune disorder which is characterized by non-scarring hair loss. Vitamin D plays an important role in immune regulation, cell growth, differentiation, and maintenance of hair cycle. AIMS AND OBJECTIVES: (1) To evaluate serum vitamin D levels in alopecia areata. (2) To compare serum vitamin D levels in new versus old cases and with respect to severity of alopecia areata. MATERIALS AND METHODS: A retrospective case–control study with 100 cases of alopecia areata and 100 age- and sex-matched healthy controls was conducted from December 2014 to November 2015. All subjects underwent complete clinical evaluation and serum vitamin D levels. Results: The mean serum vitamin D level was significantly lower in patients with alopecia areata (18.90 ± 8.32 ng/mL) (64%) as compared to healthy controls (28.21 ± 18.32 ng/mL) (38%) (P < 0.001). The mean serum vitamin D levels was significantly lower in old cases (15.11 ± 4.75 ng/mL) as compared to new cases (20.85 ± 9.09 ng/mL) (P < 0.001). The proportion of subects with vitamin D deficiency was significantly higher among old cases (84.3%) as compared to new cases (53.1%) (P < 0.05). There was a significant inverse correlation between Severity of Alopecia Tool scores and serum vitamin D levels (r = −0.298, P < 0.05). CONCLUSION: Decreased vitamin D levels were observed in patients with alopecia areata and significant inverse correlation exists between vitamin D levels and duration/severity of the disease. These findings may suggest a causal role of vitamin D deficiency in the pathogenesis and therapeutic role of vitamin D supplementation in the management of alopecia areata.
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spelling pubmed-63627552019-02-17 Evaluation of Association of Vitamin D in Alopecia Areata: A Case–control Study of 100 Patients in a Tertiary Rural Hospital of Southern India Siddappa, Harsha Kumar, Y. Hari Kishan Vivekananda, N Indian Dermatol Online J Brief Report BACKGROUND: Alopecia areata is a common autoimmune disorder which is characterized by non-scarring hair loss. Vitamin D plays an important role in immune regulation, cell growth, differentiation, and maintenance of hair cycle. AIMS AND OBJECTIVES: (1) To evaluate serum vitamin D levels in alopecia areata. (2) To compare serum vitamin D levels in new versus old cases and with respect to severity of alopecia areata. MATERIALS AND METHODS: A retrospective case–control study with 100 cases of alopecia areata and 100 age- and sex-matched healthy controls was conducted from December 2014 to November 2015. All subjects underwent complete clinical evaluation and serum vitamin D levels. Results: The mean serum vitamin D level was significantly lower in patients with alopecia areata (18.90 ± 8.32 ng/mL) (64%) as compared to healthy controls (28.21 ± 18.32 ng/mL) (38%) (P < 0.001). The mean serum vitamin D levels was significantly lower in old cases (15.11 ± 4.75 ng/mL) as compared to new cases (20.85 ± 9.09 ng/mL) (P < 0.001). The proportion of subects with vitamin D deficiency was significantly higher among old cases (84.3%) as compared to new cases (53.1%) (P < 0.05). There was a significant inverse correlation between Severity of Alopecia Tool scores and serum vitamin D levels (r = −0.298, P < 0.05). CONCLUSION: Decreased vitamin D levels were observed in patients with alopecia areata and significant inverse correlation exists between vitamin D levels and duration/severity of the disease. These findings may suggest a causal role of vitamin D deficiency in the pathogenesis and therapeutic role of vitamin D supplementation in the management of alopecia areata. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6362755/ /pubmed/30775298 http://dx.doi.org/10.4103/idoj.IDOJ_84_18 Text en Copyright: © 2019 Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Brief Report
Siddappa, Harsha
Kumar, Y. Hari Kishan
Vivekananda, N
Evaluation of Association of Vitamin D in Alopecia Areata: A Case–control Study of 100 Patients in a Tertiary Rural Hospital of Southern India
title Evaluation of Association of Vitamin D in Alopecia Areata: A Case–control Study of 100 Patients in a Tertiary Rural Hospital of Southern India
title_full Evaluation of Association of Vitamin D in Alopecia Areata: A Case–control Study of 100 Patients in a Tertiary Rural Hospital of Southern India
title_fullStr Evaluation of Association of Vitamin D in Alopecia Areata: A Case–control Study of 100 Patients in a Tertiary Rural Hospital of Southern India
title_full_unstemmed Evaluation of Association of Vitamin D in Alopecia Areata: A Case–control Study of 100 Patients in a Tertiary Rural Hospital of Southern India
title_short Evaluation of Association of Vitamin D in Alopecia Areata: A Case–control Study of 100 Patients in a Tertiary Rural Hospital of Southern India
title_sort evaluation of association of vitamin d in alopecia areata: a case–control study of 100 patients in a tertiary rural hospital of southern india
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362755/
https://www.ncbi.nlm.nih.gov/pubmed/30775298
http://dx.doi.org/10.4103/idoj.IDOJ_84_18
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