Metformin Inhibit Lung Cancer Cell Growth and Invasion in Vitro as Well as Tumor Formation in Vivo Partially by Activating PP2A

BACKGROUND: The aim of this study was to investigate whether PP2A activation is involved in the anti-cancer activity of metformin. MATERIAL/METHODS: A549 and H1651 human lung cancer cells were constructed with stable α4 overexpression (O/E α4) or knockdown of PP2A catalytic subunit A/B(sh-PP2Ac). In...

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Detalles Bibliográficos
Autores principales: Zhou, Xiaohu, Liu, Shanshan, Lin, Xuemei, Xu, Liping, Mao, Xiaoming, Liu, Jun, Zhang, Zixing, Jiang, Wenhong, Zhou, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2019
Materias:
Lab/In Vitro Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362762/
https://www.ncbi.nlm.nih.gov/pubmed/30693913
http://dx.doi.org/10.12659/MSM.912059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362762/
https://www.ncbi.nlm.nih.gov/pubmed/30693913
http://dx.doi.org/10.12659/MSM.912059

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