Cargando…
RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening
Approximately 15% of cancers use homologous recombination for alternative lengthening of telomeres (ALT). How the initiating genomic lesions invoke homology-directed telomere synthesis remains enigmatic. Here, we show that distinct dependencies exist for telomere synthesis in response to replication...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362809/ https://www.ncbi.nlm.nih.gov/pubmed/30692206 http://dx.doi.org/10.1101/gad.319723.118 |