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RAD52 and SLX4 act nonepistatically to ensure telomere stability during alternative telomere lengthening

Approximately 15% of cancers use homologous recombination for alternative lengthening of telomeres (ALT). How the initiating genomic lesions invoke homology-directed telomere synthesis remains enigmatic. Here, we show that distinct dependencies exist for telomere synthesis in response to replication...

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Detalles Bibliográficos
Autores principales: Verma, Priyanka, Dilley, Robert L., Zhang, Tianpeng, Gyparaki, Melina T., Li, Yiwen, Greenberg, Roger A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362809/
https://www.ncbi.nlm.nih.gov/pubmed/30692206
http://dx.doi.org/10.1101/gad.319723.118