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A ZNRF3-dependent Wnt/β-catenin signaling gradient is required for adrenal homeostasis

Spatiotemporal control of Wnt signaling is essential for the development and homeostasis of many tissues. The transmembrane E3 ubiquitin ligases ZNRF3 (zinc and ring finger 3) and RNF43 (ring finger protein 43) antagonize Wnt signaling by promoting degradation of frizzled receptors. ZNRF3 and RNF43...

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Detalles Bibliográficos
Autores principales:	Basham, Kaitlin J., Rodriguez, Stéphanie, Turcu, Adina F., Lerario, Antonio M., Logan, Catriona Y., Rysztak, Madeline R., Gomez-Sanchez, Celso E., Breault, David T., Koo, Bon-Kyoung, Clevers, Hans, Nusse, Roeland, Val, Pierre, Hammer, Gary D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362817/ https://www.ncbi.nlm.nih.gov/pubmed/30692207 http://dx.doi.org/10.1101/gad.317412.118

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