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Interplay of lamin A and lamin B LADs on the radial positioning of chromatin
Immunosuppressive drugs such as cyclosporin A (CsA) can elicit hepatotoxicity by affecting gene expression. Here, we address the link between CsA and large-scale chromatin organization in HepG2 hepatocarcinoma cells. We show the existence of lamina-associated domains (LADs) interacting with lamin A,...
Autores principales: | Forsberg, Frida, Brunet, Annaël, Ali, Tharvesh M. Liyakat, Collas, Philippe |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363278/ https://www.ncbi.nlm.nih.gov/pubmed/30663495 http://dx.doi.org/10.1080/19491034.2019.1570810 |
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