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The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum
Subjects with sleep apnea-hypopnea syndrome (SAHS) show an increased carotid intima-media thickness. However, no data exist about earlier markers of atheromatous disease, such as the proliferation and expansion of the adventitial vasa vasorum (VV) to the avascular intima in this setting. Our aim was...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363284/ https://www.ncbi.nlm.nih.gov/pubmed/30721271 http://dx.doi.org/10.1371/journal.pone.0211742 |
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author | López-Cano, Carolina Rius, Ferran Sánchez, Enric Gaeta, Anna Michela Betriu, Àngels Fernández, Elvira Yeramian, Andree Hernández, Marta Bueno, Marta Gutiérrez-Carrasquilla, Liliana Dalmases, Mireia Lecube, Albert |
author_facet | López-Cano, Carolina Rius, Ferran Sánchez, Enric Gaeta, Anna Michela Betriu, Àngels Fernández, Elvira Yeramian, Andree Hernández, Marta Bueno, Marta Gutiérrez-Carrasquilla, Liliana Dalmases, Mireia Lecube, Albert |
author_sort | López-Cano, Carolina |
collection | PubMed |
description | Subjects with sleep apnea-hypopnea syndrome (SAHS) show an increased carotid intima-media thickness. However, no data exist about earlier markers of atheromatous disease, such as the proliferation and expansion of the adventitial vasa vasorum (VV) to the avascular intima in this setting. Our aim was to assess carotid VV density and its relationship with sleep parameters in a cohort of obese patients without prior vascular events. A total of 55 subjects evaluated for bariatric surgery were prospectively recruited. A non-attended respiratory polygraphy was performed. The apnea-hypopnea index (AHI) and the cumulative percentage of time spent with oxygen saturation below 90% (CT90) were assessed. Serum concentrations of soluble intercellular adhesion molecule 1, P-selectin, lipocalin-2 and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured. Contrast-enhanced carotid ultrasound was used to assess the VV density. Patients with SAHS (80%) showed a higher adventitial VV density (0.801±0.125 vs. 0.697±0.082, p = 0.005) and higher levels of sVCAM-1 (745.2±137.8 vs. 643.3±122.7 ng/ml, p = 0.035) than subjects with an AHI lower than 10 events/hour. In addition, a positive association exist between mean VV density and AHI (r = 0.445, p = 0.001) and CT90 (r = 0.399, p = 0.005). Finally, in the multiple linear regression analysis, female sex, fasting plasma glucose and AHI (but not CT90) were the only variables independently associated with the mean adventitial VV density (R(2) = 0.327). In conclusion, a high VV density is present in obese subjects with SAHS, and chronic intermittent hypoxia is pointed as an independent risk factor for the development of this early step of atheromatous disease. |
format | Online Article Text |
id | pubmed-6363284 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63632842019-02-15 The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum López-Cano, Carolina Rius, Ferran Sánchez, Enric Gaeta, Anna Michela Betriu, Àngels Fernández, Elvira Yeramian, Andree Hernández, Marta Bueno, Marta Gutiérrez-Carrasquilla, Liliana Dalmases, Mireia Lecube, Albert PLoS One Research Article Subjects with sleep apnea-hypopnea syndrome (SAHS) show an increased carotid intima-media thickness. However, no data exist about earlier markers of atheromatous disease, such as the proliferation and expansion of the adventitial vasa vasorum (VV) to the avascular intima in this setting. Our aim was to assess carotid VV density and its relationship with sleep parameters in a cohort of obese patients without prior vascular events. A total of 55 subjects evaluated for bariatric surgery were prospectively recruited. A non-attended respiratory polygraphy was performed. The apnea-hypopnea index (AHI) and the cumulative percentage of time spent with oxygen saturation below 90% (CT90) were assessed. Serum concentrations of soluble intercellular adhesion molecule 1, P-selectin, lipocalin-2 and soluble vascular cell adhesion molecule 1 (sVCAM-1) were measured. Contrast-enhanced carotid ultrasound was used to assess the VV density. Patients with SAHS (80%) showed a higher adventitial VV density (0.801±0.125 vs. 0.697±0.082, p = 0.005) and higher levels of sVCAM-1 (745.2±137.8 vs. 643.3±122.7 ng/ml, p = 0.035) than subjects with an AHI lower than 10 events/hour. In addition, a positive association exist between mean VV density and AHI (r = 0.445, p = 0.001) and CT90 (r = 0.399, p = 0.005). Finally, in the multiple linear regression analysis, female sex, fasting plasma glucose and AHI (but not CT90) were the only variables independently associated with the mean adventitial VV density (R(2) = 0.327). In conclusion, a high VV density is present in obese subjects with SAHS, and chronic intermittent hypoxia is pointed as an independent risk factor for the development of this early step of atheromatous disease. Public Library of Science 2019-02-05 /pmc/articles/PMC6363284/ /pubmed/30721271 http://dx.doi.org/10.1371/journal.pone.0211742 Text en © 2019 López-Cano et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article López-Cano, Carolina Rius, Ferran Sánchez, Enric Gaeta, Anna Michela Betriu, Àngels Fernández, Elvira Yeramian, Andree Hernández, Marta Bueno, Marta Gutiérrez-Carrasquilla, Liliana Dalmases, Mireia Lecube, Albert The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum |
title | The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum |
title_full | The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum |
title_fullStr | The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum |
title_full_unstemmed | The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum |
title_short | The influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum |
title_sort | influence of sleep apnea syndrome and intermittent hypoxia in carotid adventitial vasa vasorum |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363284/ https://www.ncbi.nlm.nih.gov/pubmed/30721271 http://dx.doi.org/10.1371/journal.pone.0211742 |
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