FGF2-FGFR1 signaling regulates release of Leukemia-Protective exosomes from bone marrow stromal cells

Protective signaling from the leukemia microenvironment leads to leukemia cell persistence, development of resistance, and disease relapse. Here, we demonstrate that fibroblast growth factor 2 (FGF2) from bone marrow stromal cells is secreted in exosomes, which are subsequently endocytosed by leukem...

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Detalles Bibliográficos
Autores principales: Javidi-Sharifi, Nathalie, Martinez, Jacqueline, English, Isabel, Joshi, Sunil K, Scopim-Ribeiro, Renata, Viola, Shelton K, Edwards, David K, Agarwal, Anupriya, Lopez, Claudia, Jorgens, Danielle, Tyner, Jeffrey W, Druker, Brian J, Traer, Elie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363389/
https://www.ncbi.nlm.nih.gov/pubmed/30720426
http://dx.doi.org/10.7554/eLife.40033

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