Phosphorylation of the ryanodine receptor 2 at serine 2030 is required for a complete β-adrenergic response

During physical exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in protein kinase A (PKA)–mediated phosphorylation of the cardiac ryanodine receptor RyR2. PKA-dependent “hyperphosphorylation” of the RyR2 channel has b...

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Detalles Bibliográficos
Autores principales: Potenza, Duilio M., Janicek, Radoslav, Fernandez-Tenorio, Miguel, Camors, Emmanuel, Ramos-Mondragón, Roberto, Valdivia, Héctor H., Niggli, Ernst
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363414/
https://www.ncbi.nlm.nih.gov/pubmed/30541771
http://dx.doi.org/10.1085/jgp.201812155

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