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Noncompetitive antagonists induce cooperative AMPA receptor channel gating

Glutamate is released from presynaptic nerve terminals in the central nervous system (CNS) and spreads excitation by binding to and activating postsynaptic iGluRs. Of the potential glutamate targets, tetrameric AMPA receptors mediate fast, transient CNS signaling. Each of the four AMPA subunits in t...

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Detalles Bibliográficos
Autores principales:	Shi, Edward Y., Yuan, Christine L., Sipple, Matthew T., Srinivasan, Jayasri, Ptak, Christopher P., Oswald, Robert E., Nowak, Linda M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363417/ https://www.ncbi.nlm.nih.gov/pubmed/30622133 http://dx.doi.org/10.1085/jgp.201812209

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