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cAMP binds to closed, inactivated, and open sea urchin HCN channels in a state-dependent manner

Hyperpolarization-activated cyclic-nucleotide–modulated (HCN) channels are nonselective cation channels that regulate electrical activity in the heart and brain. Previous studies of mouse HCN2 (mHCN2) channels have shown that cAMP binds preferentially to and stabilizes these channels in the open sta...

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Detalles Bibliográficos
Autores principales:	Idikuda, Vinay, Gao, Weihua, Su, Zhuocheng, Liu, Qinglian, Zhou, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363418/ https://www.ncbi.nlm.nih.gov/pubmed/30541772 http://dx.doi.org/10.1085/jgp.201812019

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