Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice

Heterozygous loss-of-function mutations of TANK-binding kinase 1 (TBK1) cause familial ALS, yet downstream mechanisms of TBK1 mutations remained elusive. TBK1 is a pleiotropic kinase involved in the regulation of selective autophagy and inflammation. We show that heterozygous Tbk1 deletion alone doe...

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Detalles Bibliográficos
Autores principales: Brenner, David, Sieverding, Kirsten, Bruno, Clara, Lüningschrör, Patrick, Buck, Eva, Mungwa, Simon, Fischer, Lena, Brockmann, Sarah J., Ulmer, Johannes, Bliederhäuser, Corinna, Philibert, Clémentine E., Satoh, Takashi, Akira, Shizuo, Boillée, Séverine, Mayer, Benjamin, Sendtner, Michael, Ludolph, Albert C., Danzer, Karin M., Lobsiger, Christian S., Freischmidt, Axel, Weishaupt, Jochen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363427/
https://www.ncbi.nlm.nih.gov/pubmed/30635357
http://dx.doi.org/10.1084/jem.20180729

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