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Toward a better understanding of folate metabolism in health and disease

Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochond...

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Detalles Bibliográficos
Autores principales: Zheng, Yuxiang, Cantley, Lewis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363433/
https://www.ncbi.nlm.nih.gov/pubmed/30587505
http://dx.doi.org/10.1084/jem.20181965
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author Zheng, Yuxiang
Cantley, Lewis C.
author_facet Zheng, Yuxiang
Cantley, Lewis C.
author_sort Zheng, Yuxiang
collection PubMed
description Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. Not surprisingly, abnormal folate metabolism has been causally linked with a myriad of diseases. In this review, we provide a historical perspective, delve into folate chemistry that is often overlooked, and point out various missing links and underdeveloped areas in folate metabolism for future exploration.
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spelling pubmed-63634332019-08-04 Toward a better understanding of folate metabolism in health and disease Zheng, Yuxiang Cantley, Lewis C. J Exp Med Reviews Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. Not surprisingly, abnormal folate metabolism has been causally linked with a myriad of diseases. In this review, we provide a historical perspective, delve into folate chemistry that is often overlooked, and point out various missing links and underdeveloped areas in folate metabolism for future exploration. Rockefeller University Press 2019-02-04 /pmc/articles/PMC6363433/ /pubmed/30587505 http://dx.doi.org/10.1084/jem.20181965 Text en © 2018 Zheng and Cantley http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Reviews
Zheng, Yuxiang
Cantley, Lewis C.
Toward a better understanding of folate metabolism in health and disease
title Toward a better understanding of folate metabolism in health and disease
title_full Toward a better understanding of folate metabolism in health and disease
title_fullStr Toward a better understanding of folate metabolism in health and disease
title_full_unstemmed Toward a better understanding of folate metabolism in health and disease
title_short Toward a better understanding of folate metabolism in health and disease
title_sort toward a better understanding of folate metabolism in health and disease
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363433/
https://www.ncbi.nlm.nih.gov/pubmed/30587505
http://dx.doi.org/10.1084/jem.20181965
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