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Toward a better understanding of folate metabolism in health and disease
Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochond...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rockefeller University Press
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363433/ https://www.ncbi.nlm.nih.gov/pubmed/30587505 http://dx.doi.org/10.1084/jem.20181965 |
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author | Zheng, Yuxiang Cantley, Lewis C. |
author_facet | Zheng, Yuxiang Cantley, Lewis C. |
author_sort | Zheng, Yuxiang |
collection | PubMed |
description | Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. Not surprisingly, abnormal folate metabolism has been causally linked with a myriad of diseases. In this review, we provide a historical perspective, delve into folate chemistry that is often overlooked, and point out various missing links and underdeveloped areas in folate metabolism for future exploration. |
format | Online Article Text |
id | pubmed-6363433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63634332019-08-04 Toward a better understanding of folate metabolism in health and disease Zheng, Yuxiang Cantley, Lewis C. J Exp Med Reviews Folate metabolism is crucial for many biochemical processes, including purine and thymidine monophosphate (dTMP) biosynthesis, mitochondrial protein translation, and methionine regeneration. These biochemical processes in turn support critical cellular functions such as cell proliferation, mitochondrial respiration, and epigenetic regulation. Not surprisingly, abnormal folate metabolism has been causally linked with a myriad of diseases. In this review, we provide a historical perspective, delve into folate chemistry that is often overlooked, and point out various missing links and underdeveloped areas in folate metabolism for future exploration. Rockefeller University Press 2019-02-04 /pmc/articles/PMC6363433/ /pubmed/30587505 http://dx.doi.org/10.1084/jem.20181965 Text en © 2018 Zheng and Cantley http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Reviews Zheng, Yuxiang Cantley, Lewis C. Toward a better understanding of folate metabolism in health and disease |
title | Toward a better understanding of folate metabolism in health and disease |
title_full | Toward a better understanding of folate metabolism in health and disease |
title_fullStr | Toward a better understanding of folate metabolism in health and disease |
title_full_unstemmed | Toward a better understanding of folate metabolism in health and disease |
title_short | Toward a better understanding of folate metabolism in health and disease |
title_sort | toward a better understanding of folate metabolism in health and disease |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363433/ https://www.ncbi.nlm.nih.gov/pubmed/30587505 http://dx.doi.org/10.1084/jem.20181965 |
work_keys_str_mv | AT zhengyuxiang towardabetterunderstandingoffolatemetabolisminhealthanddisease AT cantleylewisc towardabetterunderstandingoffolatemetabolisminhealthanddisease |