Cargando…

P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X...

Descripción completa

Detalles Bibliográficos
Autores principales:	Faliti, Caterina E., Gualtierotti, Roberta, Rottoli, Elsa, Gerosa, Maria, Perruzza, Lisa, Romagnani, Andrea, Pellegrini, Giovanni, De Ponte Conti, Benedetta, Rossi, Riccardo L., Idzko, Marco, Mazza, Emilia M.C., Bicciato, Silvio, Traggiai, Elisabetta, Meroni, Pier Luigi, Grassi, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363434/ https://www.ncbi.nlm.nih.gov/pubmed/30655308 http://dx.doi.org/10.1084/jem.20171976

Ejemplares similares

Inhibition of Aberrant Circulating Tfh Cell Proportions by Corticosteroids in Patients with Systemic Lupus Erythematosus
por: Feng, Xuebing, et al.
Publicado: (2012)

The P2X7 Receptor in Tumor Immunity
por: Grassi, Fabio, et al.
Publicado: (2021)

Regulators of Tfh Cell Differentiation
por: Jogdand, Gajendra M., et al.
Publicado: (2016)

TFH cells in systemic sclerosis
por: Beurier, Pauline, et al.
Publicado: (2021)

Circulating memory T follicular helper subsets, Tfh2 and Tfh17, participate in the pathogenesis of Guillain-Barré syndrome
por: Che, Yuanyuan, et al.
Publicado: (2016)

Functions of Tfh Cells in Common Variable Immunodeficiency
por: Le Saos-Patrinos, Corentin, et al.
Publicado: (2020)

Circulating Tfh1 (cTfh1) cell numbers and PD1 expression are elevated in low-grade B-cell non-Hodgkin’s lymphoma and cTfh gene expression is perturbed in marginal zone lymphoma
por: Byford, Elliot T., et al.
Publicado: (2018)

Clinical and serological features of juvenile systemic lupus erythematosus in an italian tertiary centre of pediatric rheumatology
por: Pontikaki, Irene, et al.
Publicado: (2014)

Translational regulation of TFH cell differentiation and autoimmune pathogenesis
por: Patel, Preeyam S., et al.
Publicado: (2022)

Deciphering the spectrum of cutaneous lymphomas expressing TFH markers
por: Donzel, Marie, et al.
Publicado: (2023)

Editorial: Systemic Lupus Erythematosus and Antiphospholipid Syndrome
por: Meroni, Pier Luigi, et al.
Publicado: (2019)

Antiglutamate Receptor Antibodies and Cognitive Impairment in Primary Antiphospholipid Syndrome and Systemic Lupus Erythematosus
por: Gerosa, Maria, et al.
Publicado: (2016)

The Ratio of CD226 and TIGIT Expression in Tfh and PD-1(+)ICOS(+)Tfh Cells Are Potential Biomarkers for Chronic Antibody-Mediated Rejection in Kidney Transplantation
por: Fan, Ji-wen, et al.
Publicado: (2022)

Antibodies against type I IFN: The bad guys self-restrain in systemic lupus erythematosus
por: Fillatreau, Simon
Publicado: (2023)

Follicular Helper T (Tfh) Cells in Autoimmune Diseases and Allograft Rejection
por: Jeon, Yun-Hui, et al.
Publicado: (2016)

Role of TFH Cells in Promoting T Helper 17-Induced Neuroinflammation
por: Quinn, James L., et al.
Publicado: (2018)

Imbalance of Circulating Tfh/Tfr Cells in Patients With Parkinson's Disease
por: Zhao, Xiuzhen, et al.
Publicado: (2020)

Dynamic Regulation of Tfh Selection During the Germinal Center Reaction
por: Merkenschlager, Julia, et al.
Publicado: (2021)

Platelet desialylation and TFH cells–the novel pathway of immune thrombocytopenia
por: Chen, Yuwen, et al.
Publicado: (2021)

Association between Tfh and PGA in children with Henoch–Schönlein purpura
por: Meihua, Miao, et al.
Publicado: (2021)

LncRNA IL21‐AS1 interacts with hnRNPU protein to promote IL21 overexpression and aberrant differentiation of Tfh cells in systemic lupus erythematosus
por: Liu, Limin, et al.
Publicado: (2022)

Peli1 negatively regulates noncanonical NF-κB signaling to restrain systemic lupus erythematosus
por: Liu, Junli, et al.
Publicado: (2018)

Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques
por: Moukambi, Félicien, et al.
Publicado: (2015)

Deficiency of Tfh Cells and Germinal Center in Deceased COVID-19 Patients
por: Duan, Ya-qi, et al.
Publicado: (2020)

Regulatory Effect of Sishen Pill on Tfh Cells in Mice With Experimental Colitis
por: Liu, Xue-Ke, et al.
Publicado: (2020)

CD226 and TIGIT Cooperate in the Differentiation and Maturation of Human Tfh Cells
por: Yasutomi, Motoko, et al.
Publicado: (2022)

Cytokine-skewed Tfh cells: functional consequences for B cell help
por: Olatunde, Adesola C., et al.
Publicado: (2021)

mTOR-dependent translation drives tumor infiltrating CD8(+) effector and CD4(+) Treg cells expansion
por: De Ponte Conti, Benedetta, et al.
Publicado: (2021)

Inhibition of IL-17 ameliorates systemic lupus erythematosus in Roquin(san/san) mice through regulating the balance of TFH cells, GC B cells, Treg and Breg
por: Lee, Seon-yeong, et al.
Publicado: (2019)

IL-21–producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts
por: Zhang, Hengcheng, et al.
Publicado: (2023)

Grammatical-Restrained Hidden Conditional Random Fields for Bioinformatics applications
por: Fariselli, Piero, et al.
Publicado: (2009)

Follicular Helper T Cells (Tfh) and IL-21 Involvement in the Pathogenesis of Bullous Pemphigoid
por: Li, Qiuju, et al.
Publicado: (2013)

Correction: Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques
por: Moukambi, Félicien, et al.
Publicado: (2016)

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms
por: Hatzi, Katerina, et al.
Publicado: (2015)

Tfh1 Cells in Germinal Centers During Chronic HIV/SIV Infection
por: Velu, Vijayakumar, et al.
Publicado: (2018)

T-bet in Tfh cells: Now you see me, now you don’t
por: Kaech, Susan M.
Publicado: (2018)

γδTFH cells promote B cell maturation and antibody production in neuroblastoma
por: Mou, Wenjun, et al.
Publicado: (2017)

Sleep Disturbance during Infection Compromises Tfh Differentiation and Impacts Host Immunity
por: Fernandes, Edgar Ruz, et al.
Publicado: (2020)

Tfh Cells in Health and Immunity: Potential Targets for Systems Biology Approaches to Vaccination
por: Law, Hannah, et al.
Publicado: (2020)

Stepwise Tfh cell differentiation revisited: new advances and long-standing questions
por: Schroeder, Andrew R, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3oqsoeabveu2nd8obd74k3u89c