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P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus

Altered control of T follicular helper (Tfh) cells can lead to generation of autoantibodies and autoimmune manifestations. Signaling pathways that selectively limit pathogenic responses without affecting the protective function of Tfh cells are unknown. Here we show that the ATP-gated ionotropic P2X...

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Detalles Bibliográficos
Autores principales:	Faliti, Caterina E., Gualtierotti, Roberta, Rottoli, Elsa, Gerosa, Maria, Perruzza, Lisa, Romagnani, Andrea, Pellegrini, Giovanni, De Ponte Conti, Benedetta, Rossi, Riccardo L., Idzko, Marco, Mazza, Emilia M.C., Bicciato, Silvio, Traggiai, Elisabetta, Meroni, Pier Luigi, Grassi, Fabio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363434/ https://www.ncbi.nlm.nih.gov/pubmed/30655308 http://dx.doi.org/10.1084/jem.20171976

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