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Mitotic regulators TPX2 and Aurora A protect DNA forks during replication stress by counteracting 53BP1 function

53BP1 is a chromatin-associated protein that regulates the DNA damage response. In this study, we identify the TPX2/Aurora A heterodimer, nominally considered a mitotic kinase complex, as a novel binding partner of 53BP1. We find that TPX2/Aurora A plays a previously unrecognized role in DNA damage...

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Detalles Bibliográficos
Autores principales:	Byrum, Andrea K., Carvajal-Maldonado, Denisse, Mudge, Miranda C., Valle-Garcia, David, Majid, Mona C., Patel, Romil, Sowa, Mathew E., Gygi, Steven P., Harper, J. Wade, Shi, Yang, Vindigni, Alessandro, Mosammaparast, Nima
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363440/ https://www.ncbi.nlm.nih.gov/pubmed/30602538 http://dx.doi.org/10.1083/jcb.201803003

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