Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin

Saccharopine, a nonproteinogenic amino acid originally isolated from the yeast Saccharomyces cerevisiae, is an intermediate in lysine metabolism. In this issue, Zhou et al. (2019. J. Cell Biol. https://doi.org./10.1083/jcb.201807204) show that abnormal accumulation of saccharopine results in defecti...

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Detalles Bibliográficos
Autores principales: Leandro, João, Houten, Sander M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Commentaries
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363453/
https://www.ncbi.nlm.nih.gov/pubmed/30651301
http://dx.doi.org/10.1083/jcb.201901033
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author Leandro, João
Houten, Sander M.
author_facet Leandro, João
Houten, Sander M.
author_sort Leandro, João
collection PubMed
description Saccharopine, a nonproteinogenic amino acid originally isolated from the yeast Saccharomyces cerevisiae, is an intermediate in lysine metabolism. In this issue, Zhou et al. (2019. J. Cell Biol. https://doi.org./10.1083/jcb.201807204) show that abnormal accumulation of saccharopine results in defective mitochondrial dynamics and function in worm and mouse models.
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spelling pubmed-63634532019-08-04 Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin Leandro, João Houten, Sander M. J Cell Biol Commentaries Saccharopine, a nonproteinogenic amino acid originally isolated from the yeast Saccharomyces cerevisiae, is an intermediate in lysine metabolism. In this issue, Zhou et al. (2019. J. Cell Biol. https://doi.org./10.1083/jcb.201807204) show that abnormal accumulation of saccharopine results in defective mitochondrial dynamics and function in worm and mouse models. Rockefeller University Press 2019-02-04 /pmc/articles/PMC6363453/ /pubmed/30651301 http://dx.doi.org/10.1083/jcb.201901033 Text en © 2019 Leandro and Houten http://www.rupress.org/terms/https://creativecommons.org/licenses/by-nc-sa/4.0/This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Commentaries
Leandro, João
Houten, Sander M.
Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin
title Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin
title_full Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin
title_fullStr Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin
title_full_unstemmed Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin
title_short Saccharopine, a lysine degradation intermediate, is a mitochondrial toxin
title_sort saccharopine, a lysine degradation intermediate, is a mitochondrial toxin
topic Commentaries
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363453/
https://www.ncbi.nlm.nih.gov/pubmed/30651301
http://dx.doi.org/10.1083/jcb.201901033
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