The lysine catabolite saccharopine impairs development by disrupting mitochondrial homeostasis

Amino acid catabolism is frequently executed in mitochondria; however, it is largely unknown how aberrant amino acid metabolism affects mitochondria. Here we report the requirement for mitochondrial saccharopine degradation in mitochondrial homeostasis and animal development. In Caenorhbditis elegan...

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Detalles Bibliográficos
Autores principales: Zhou, Junxiang, Wang, Xin, Wang, Min, Chang, Yuwei, Zhang, Fengxia, Ban, Zhaonan, Tang, Ruofeng, Gan, Qiwen, Wu, Shaohuan, Guo, Ye, Zhang, Qian, Wang, Fengyang, Zhao, Liyuan, Jing, Yudong, Qian, Wenfeng, Wang, Guodong, Guo, Weixiang, Yang, Chonglin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2019
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363459/
https://www.ncbi.nlm.nih.gov/pubmed/30573525
http://dx.doi.org/10.1083/jcb.201807204

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363459/
https://www.ncbi.nlm.nih.gov/pubmed/30573525
http://dx.doi.org/10.1083/jcb.201807204

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