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A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor

Intramembrane proteolysis of transmembrane substrates by the presenilin–γ-secretase complex is preceded and regulated by shedding of the substrate’s ectodomain by α- or β-secretase. We asked whether β- and γ-secretases interact to mediate efficient sequential processing of APP, generating the amyloi...

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Detalles Bibliográficos
Autores principales:	Liu, Lei, Ding, Li, Rovere, Matteo, Wolfe, Michael S., Selkoe, Dennis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2019
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363461/ https://www.ncbi.nlm.nih.gov/pubmed/30626721 http://dx.doi.org/10.1083/jcb.201806205

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