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Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness

A key question in neuroscience is how cortical organisation relates to experience. Previously we showed that amputees experiencing highly vivid phantom sensations maintain cortical representation of their missing hand (Kikkert et al., 2016). Here, we examined the role of sensory hand experience on p...

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Autores principales: Wesselink, Daan B, van den Heiligenberg, Fiona MZ, Ejaz, Naveed, Dempsey-Jones, Harriet, Cardinali, Lucilla, Tarall-Jozwiak, Aurelie, Diedrichsen, Jörn, Makin, Tamar R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363469/
https://www.ncbi.nlm.nih.gov/pubmed/30717824
http://dx.doi.org/10.7554/eLife.37227
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author Wesselink, Daan B
van den Heiligenberg, Fiona MZ
Ejaz, Naveed
Dempsey-Jones, Harriet
Cardinali, Lucilla
Tarall-Jozwiak, Aurelie
Diedrichsen, Jörn
Makin, Tamar R
author_facet Wesselink, Daan B
van den Heiligenberg, Fiona MZ
Ejaz, Naveed
Dempsey-Jones, Harriet
Cardinali, Lucilla
Tarall-Jozwiak, Aurelie
Diedrichsen, Jörn
Makin, Tamar R
author_sort Wesselink, Daan B
collection PubMed
description A key question in neuroscience is how cortical organisation relates to experience. Previously we showed that amputees experiencing highly vivid phantom sensations maintain cortical representation of their missing hand (Kikkert et al., 2016). Here, we examined the role of sensory hand experience on persistent hand representation by studying individuals with acquired and congenital hand loss. We used representational similarity analysis in primary somatosensory and motor cortex during missing and intact hand movements. We found that key aspects of acquired amputees’ missing hand representation persisted, despite varying vividness of phantom sensations. In contrast, missing hand representation of congenital one-handers, who do not experience phantom sensations, was significantly reduced. Across acquired amputees, individuals’ reported motor control over their phantom hand positively correlated with the extent to which their somatosensory hand representation was normally organised. We conclude that once cortical organisation is formed, it is remarkably persistent, despite long-term attenuation of peripheral signals.
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spelling pubmed-63634692019-02-07 Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness Wesselink, Daan B van den Heiligenberg, Fiona MZ Ejaz, Naveed Dempsey-Jones, Harriet Cardinali, Lucilla Tarall-Jozwiak, Aurelie Diedrichsen, Jörn Makin, Tamar R eLife Neuroscience A key question in neuroscience is how cortical organisation relates to experience. Previously we showed that amputees experiencing highly vivid phantom sensations maintain cortical representation of their missing hand (Kikkert et al., 2016). Here, we examined the role of sensory hand experience on persistent hand representation by studying individuals with acquired and congenital hand loss. We used representational similarity analysis in primary somatosensory and motor cortex during missing and intact hand movements. We found that key aspects of acquired amputees’ missing hand representation persisted, despite varying vividness of phantom sensations. In contrast, missing hand representation of congenital one-handers, who do not experience phantom sensations, was significantly reduced. Across acquired amputees, individuals’ reported motor control over their phantom hand positively correlated with the extent to which their somatosensory hand representation was normally organised. We conclude that once cortical organisation is formed, it is remarkably persistent, despite long-term attenuation of peripheral signals. eLife Sciences Publications, Ltd 2019-02-05 /pmc/articles/PMC6363469/ /pubmed/30717824 http://dx.doi.org/10.7554/eLife.37227 Text en © 2019, Wesselink et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Neuroscience
Wesselink, Daan B
van den Heiligenberg, Fiona MZ
Ejaz, Naveed
Dempsey-Jones, Harriet
Cardinali, Lucilla
Tarall-Jozwiak, Aurelie
Diedrichsen, Jörn
Makin, Tamar R
Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness
title Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness
title_full Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness
title_fullStr Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness
title_full_unstemmed Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness
title_short Obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness
title_sort obtaining and maintaining cortical hand representation as evidenced from acquired and congenital handlessness
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363469/
https://www.ncbi.nlm.nih.gov/pubmed/30717824
http://dx.doi.org/10.7554/eLife.37227
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