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Antithyroid Antibodies and Thyroid Dysfunction in Saudi Children with Down Syndrome

Fifty children (ages seven months to nine years) with Down syndrome compared with age and sex matched controls were tested for antithyroid antibodies. Seven (14%) of the Down group were found to be seropositive; six (12%) for antimicrosomal antibodies; three for both antimicrosomal and antithyroglob...

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Autores principales: Abdullah, Mohamed Ahmed, Salman, Hussain, Al-Habib, Sulaiman, Ghareeb, Abdulrahman, Abanamy, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: King Faisal Specialist Hospital and Research Centre 1994
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363516/
https://www.ncbi.nlm.nih.gov/pubmed/17586918
http://dx.doi.org/10.5144/0256-4947.1994.283
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author Abdullah, Mohamed Ahmed
Salman, Hussain
Al-Habib, Sulaiman
Ghareeb, Abdulrahman
Abanamy, Ahmed
author_facet Abdullah, Mohamed Ahmed
Salman, Hussain
Al-Habib, Sulaiman
Ghareeb, Abdulrahman
Abanamy, Ahmed
author_sort Abdullah, Mohamed Ahmed
collection PubMed
description Fifty children (ages seven months to nine years) with Down syndrome compared with age and sex matched controls were tested for antithyroid antibodies. Seven (14%) of the Down group were found to be seropositive; six (12%) for antimicrosomal antibodies; three for both antimicrosomal and antithyroglobulin; none was positive for antithyroglobulin alone. All the control group were seronegative and had no clinical evidence of thyroid disease. Three (6%) of the Down group had hypothyroidism, two due to autoimmune thyroiditis and one had thyroid dysgenesis; one of the previous two had insulin dependent diabetes mellitus. One child had Graves disease. Thyroid dysfunction was not previously suspected in the two symptomatic children. In view of our findings, recommendations are made to regularly screen these children for autoantibodies and evidence of thyroid dysfunction.
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spelling pubmed-63635162019-02-25 Antithyroid Antibodies and Thyroid Dysfunction in Saudi Children with Down Syndrome Abdullah, Mohamed Ahmed Salman, Hussain Al-Habib, Sulaiman Ghareeb, Abdulrahman Abanamy, Ahmed Ann Saudi Med Original Article Fifty children (ages seven months to nine years) with Down syndrome compared with age and sex matched controls were tested for antithyroid antibodies. Seven (14%) of the Down group were found to be seropositive; six (12%) for antimicrosomal antibodies; three for both antimicrosomal and antithyroglobulin; none was positive for antithyroglobulin alone. All the control group were seronegative and had no clinical evidence of thyroid disease. Three (6%) of the Down group had hypothyroidism, two due to autoimmune thyroiditis and one had thyroid dysgenesis; one of the previous two had insulin dependent diabetes mellitus. One child had Graves disease. Thyroid dysfunction was not previously suspected in the two symptomatic children. In view of our findings, recommendations are made to regularly screen these children for autoantibodies and evidence of thyroid dysfunction. King Faisal Specialist Hospital and Research Centre 1994-07-01 1994 /pmc/articles/PMC6363516/ /pubmed/17586918 http://dx.doi.org/10.5144/0256-4947.1994.283 Text en Copyright © 1994, Annals of Saudi Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Abdullah, Mohamed Ahmed
Salman, Hussain
Al-Habib, Sulaiman
Ghareeb, Abdulrahman
Abanamy, Ahmed
Antithyroid Antibodies and Thyroid Dysfunction in Saudi Children with Down Syndrome
title Antithyroid Antibodies and Thyroid Dysfunction in Saudi Children with Down Syndrome
title_full Antithyroid Antibodies and Thyroid Dysfunction in Saudi Children with Down Syndrome
title_fullStr Antithyroid Antibodies and Thyroid Dysfunction in Saudi Children with Down Syndrome
title_full_unstemmed Antithyroid Antibodies and Thyroid Dysfunction in Saudi Children with Down Syndrome
title_short Antithyroid Antibodies and Thyroid Dysfunction in Saudi Children with Down Syndrome
title_sort antithyroid antibodies and thyroid dysfunction in saudi children with down syndrome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363516/
https://www.ncbi.nlm.nih.gov/pubmed/17586918
http://dx.doi.org/10.5144/0256-4947.1994.283
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