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Albumin-linked prostate-specific antigen-activated thapsigargin- and niclosamide-based molecular grenades targeting the microenvironment in metastatic castration-resistant prostate cancer

Localized prostate cancer is curable via annihilation of the entire cancer neighborhood by surgery or local radiation. Unfortunately, once metastatic, no available therapy is curative. The vast majority will die despite aggressive systemic combinational androgen-ablation therapies. Thus, there is an...

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Detalles Bibliográficos
Autores principales: Akinboye, Emmanuel S., Brennen, W. Nathaniel, Denmeade, Samuel R., Isaacs, John T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Second Military Medical University 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363604/
https://www.ncbi.nlm.nih.gov/pubmed/30775253
http://dx.doi.org/10.1016/j.ajur.2018.11.004