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Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics

This article describes cell signaling network of metastatic prostate cancer (PCa) to bone and visceral organs in the context of tumor microenvironment and for the development of novel therapeutics. The article focuses on our recent progress in the understanding of: 1) The plasticity and dynamics of...

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Autores principales: Chu, Gina Chia-Yi, Chung, Leland W.K., Gururajan, Murali, Hsieh, Chia-Ling, Josson, Sajni, Nandana, Srinivas, Sung, Shian-Ying, Wang, Ruoxiang, Wu, Jason Boyang, Zhau, Haiyen E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Second Military Medical University 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363607/
https://www.ncbi.nlm.nih.gov/pubmed/30775250
http://dx.doi.org/10.1016/j.ajur.2018.11.003
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author Chu, Gina Chia-Yi
Chung, Leland W.K.
Gururajan, Murali
Hsieh, Chia-Ling
Josson, Sajni
Nandana, Srinivas
Sung, Shian-Ying
Wang, Ruoxiang
Wu, Jason Boyang
Zhau, Haiyen E.
author_facet Chu, Gina Chia-Yi
Chung, Leland W.K.
Gururajan, Murali
Hsieh, Chia-Ling
Josson, Sajni
Nandana, Srinivas
Sung, Shian-Ying
Wang, Ruoxiang
Wu, Jason Boyang
Zhau, Haiyen E.
author_sort Chu, Gina Chia-Yi
collection PubMed
description This article describes cell signaling network of metastatic prostate cancer (PCa) to bone and visceral organs in the context of tumor microenvironment and for the development of novel therapeutics. The article focuses on our recent progress in the understanding of: 1) The plasticity and dynamics of tumor–stroma interaction; 2) The significance of epigenetic reprogramming in conferring cancer growth, invasion and metastasis; 3) New insights on altered junctional communication affecting PCa bone and brain metastases; 4) Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy; 5) Genetic-based therapy to co-target tumor and bone stroma; 6) PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis; 7) The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis; and 8) Characterization of imprinting cluster of microRNA, in tumor–stroma interaction. This article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical translation. This article referenced the details of the various approaches and discoveries described herein in peer-reviewed publications. We dedicate this article in our fond memory of Dr. Donald S. Coffey who taught us the spirit of sharing and the importance of focusing basic science discoveries toward translational medicine.
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spelling pubmed-63636072019-02-15 Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics Chu, Gina Chia-Yi Chung, Leland W.K. Gururajan, Murali Hsieh, Chia-Ling Josson, Sajni Nandana, Srinivas Sung, Shian-Ying Wang, Ruoxiang Wu, Jason Boyang Zhau, Haiyen E. Asian J Urol Review This article describes cell signaling network of metastatic prostate cancer (PCa) to bone and visceral organs in the context of tumor microenvironment and for the development of novel therapeutics. The article focuses on our recent progress in the understanding of: 1) The plasticity and dynamics of tumor–stroma interaction; 2) The significance of epigenetic reprogramming in conferring cancer growth, invasion and metastasis; 3) New insights on altered junctional communication affecting PCa bone and brain metastases; 4) Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy; 5) Genetic-based therapy to co-target tumor and bone stroma; 6) PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis; 7) The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis; and 8) Characterization of imprinting cluster of microRNA, in tumor–stroma interaction. This article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical translation. This article referenced the details of the various approaches and discoveries described herein in peer-reviewed publications. We dedicate this article in our fond memory of Dr. Donald S. Coffey who taught us the spirit of sharing and the importance of focusing basic science discoveries toward translational medicine. Second Military Medical University 2019-01 2018-11-28 /pmc/articles/PMC6363607/ /pubmed/30775250 http://dx.doi.org/10.1016/j.ajur.2018.11.003 Text en © 2019 Editorial Office of Asian Journal of Urology. Production and hosting by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review
Chu, Gina Chia-Yi
Chung, Leland W.K.
Gururajan, Murali
Hsieh, Chia-Ling
Josson, Sajni
Nandana, Srinivas
Sung, Shian-Ying
Wang, Ruoxiang
Wu, Jason Boyang
Zhau, Haiyen E.
Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics
title Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics
title_full Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics
title_fullStr Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics
title_full_unstemmed Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics
title_short Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics
title_sort regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363607/
https://www.ncbi.nlm.nih.gov/pubmed/30775250
http://dx.doi.org/10.1016/j.ajur.2018.11.003
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