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Role of Myokines in Regulating Skeletal Muscle Mass and Function
Loss of skeletal muscle mass and strength has recently become a hot research topic with the extension of life span and an increasingly sedentary lifestyle in modern society. Maintenance of skeletal muscle mass is considered an essential determinant of muscle strength and function. Myokines are cytok...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363662/ https://www.ncbi.nlm.nih.gov/pubmed/30761018 http://dx.doi.org/10.3389/fphys.2019.00042 |
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author | Lee, Jong Han Jun, Hee-Sook |
author_facet | Lee, Jong Han Jun, Hee-Sook |
author_sort | Lee, Jong Han |
collection | PubMed |
description | Loss of skeletal muscle mass and strength has recently become a hot research topic with the extension of life span and an increasingly sedentary lifestyle in modern society. Maintenance of skeletal muscle mass is considered an essential determinant of muscle strength and function. Myokines are cytokines synthesized and released by myocytes during muscular contractions. They are implicated in autocrine regulation of metabolism in the muscle as well as in the paracrine/endocrine regulation of other tissues and organs including adipose tissue, the liver, and the brain through their receptors. Till date, secretome analysis of human myocyte culture medium has revealed over 600 myokines. In this review article, we summarize our current knowledge of major identified and characterized myokines focusing on their biological activity and function, particularly in muscle mass and function. |
format | Online Article Text |
id | pubmed-6363662 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-63636622019-02-13 Role of Myokines in Regulating Skeletal Muscle Mass and Function Lee, Jong Han Jun, Hee-Sook Front Physiol Physiology Loss of skeletal muscle mass and strength has recently become a hot research topic with the extension of life span and an increasingly sedentary lifestyle in modern society. Maintenance of skeletal muscle mass is considered an essential determinant of muscle strength and function. Myokines are cytokines synthesized and released by myocytes during muscular contractions. They are implicated in autocrine regulation of metabolism in the muscle as well as in the paracrine/endocrine regulation of other tissues and organs including adipose tissue, the liver, and the brain through their receptors. Till date, secretome analysis of human myocyte culture medium has revealed over 600 myokines. In this review article, we summarize our current knowledge of major identified and characterized myokines focusing on their biological activity and function, particularly in muscle mass and function. Frontiers Media S.A. 2019-01-30 /pmc/articles/PMC6363662/ /pubmed/30761018 http://dx.doi.org/10.3389/fphys.2019.00042 Text en Copyright © 2019 Lee and Jun. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Lee, Jong Han Jun, Hee-Sook Role of Myokines in Regulating Skeletal Muscle Mass and Function |
title | Role of Myokines in Regulating Skeletal Muscle Mass and Function |
title_full | Role of Myokines in Regulating Skeletal Muscle Mass and Function |
title_fullStr | Role of Myokines in Regulating Skeletal Muscle Mass and Function |
title_full_unstemmed | Role of Myokines in Regulating Skeletal Muscle Mass and Function |
title_short | Role of Myokines in Regulating Skeletal Muscle Mass and Function |
title_sort | role of myokines in regulating skeletal muscle mass and function |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363662/ https://www.ncbi.nlm.nih.gov/pubmed/30761018 http://dx.doi.org/10.3389/fphys.2019.00042 |
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