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SIX1 represses senescence and promotes SOX2-mediated cellular plasticity during tumorigenesis
Six1 is a developmental transcriptional regulator frequently overexpressed in human tumors. Recent results show that SIX1 also acts as a repressor of cell senescence, an antiproliferative response with a key role in tumor suppression, among other physiological and pathological settings. Here, we set...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363751/ https://www.ncbi.nlm.nih.gov/pubmed/30723235 http://dx.doi.org/10.1038/s41598-018-38176-0 |