Zinc regulates ERp44-dependent protein quality control in the early secretory pathway

Zinc ions (Zn(2+)) are imported into the early secretory pathway by Golgi-resident transporters, but their handling and functions are not fully understood. Here, we show that Zn(2+) binds with high affinity to the pH-sensitive chaperone ERp44, modulating its localization and ability to retrieve clie...

Descripción completa

Detalles Bibliográficos
Autores principales: Watanabe, Satoshi, Amagai, Yuta, Sannino, Sara, Tempio, Tiziana, Anelli, Tiziana, Harayama, Manami, Masui, Shoji, Sorrentino, Ilaria, Yamada, Momo, Sitia, Roberto, Inaba, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363758/
https://www.ncbi.nlm.nih.gov/pubmed/30723194
http://dx.doi.org/10.1038/s41467-019-08429-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363758/
https://www.ncbi.nlm.nih.gov/pubmed/30723194
http://dx.doi.org/10.1038/s41467-019-08429-1

Ejemplares similares