Inhibition of FAK Signaling Elicits Lamin A/C-Associated Nuclear Deformity and Cellular Senescence

Focal adhesion kinase (FAK) is a non-receptor kinase that facilitates tumor aggressiveness. The effects of FAK inhibition include arresting proliferation, limiting metastasis, and inhibiting angiogenesis. PF-573228 is an ATP-competitive inhibitor of FAK. Treating lung cancer cells with PF-573228 res...

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Detalles Bibliográficos
Autores principales: Chuang, Hsiang-Hao, Wang, Pei-Hui, Niu, Sheng-Wen, Zhen, Yen-Yi, Huang, Ming-Shyan, Hsiao, Michael, Yang, Chih-Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363943/
https://www.ncbi.nlm.nih.gov/pubmed/30761269
http://dx.doi.org/10.3389/fonc.2019.00022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363943/
https://www.ncbi.nlm.nih.gov/pubmed/30761269
http://dx.doi.org/10.3389/fonc.2019.00022

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