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Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix

The physical remodeling associated with cancer progression results in barriers to mass transport in the tumor interstitial space. This hindrance ultimately affects the distribution of macromolecules that govern cell fate and potency of cancer therapies. Therefore, knowing how specific extracellular...

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Detalles Bibliográficos
Autores principales: Avendano, Alex, Cortes-Medina, Marcos, Song, Jonathan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364047/
https://www.ncbi.nlm.nih.gov/pubmed/30761297
http://dx.doi.org/10.3389/fbioe.2019.00006
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author Avendano, Alex
Cortes-Medina, Marcos
Song, Jonathan W.
author_facet Avendano, Alex
Cortes-Medina, Marcos
Song, Jonathan W.
author_sort Avendano, Alex
collection PubMed
description The physical remodeling associated with cancer progression results in barriers to mass transport in the tumor interstitial space. This hindrance ultimately affects the distribution of macromolecules that govern cell fate and potency of cancer therapies. Therefore, knowing how specific extracellular matrix (ECM) and cellular components regulate transport in the tumor interstitium could lead to matrix normalizing strategies that improve patient outcome. Studies over the past decades have provided quantitative insights into interstitial transport in tumors by characterizing two governing parameters: (1) molecular diffusivity and (2) hydraulic conductivity. However, many of the conventional techniques used to measure these parameters are limited due to their inability to experimentally manipulate the physical and cellular environments of tumors. Here, we examine the application and future opportunities of microfluidic systems for identifying the physiochemical mediators of mass transport in the tumor ECM. Further advancement and adoption of microfluidic systems to quantify tumor transport parameters has potential to bridge basic science with translational research for advancing personalized medicine in oncology.
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spelling pubmed-63640472019-02-13 Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix Avendano, Alex Cortes-Medina, Marcos Song, Jonathan W. Front Bioeng Biotechnol Bioengineering and Biotechnology The physical remodeling associated with cancer progression results in barriers to mass transport in the tumor interstitial space. This hindrance ultimately affects the distribution of macromolecules that govern cell fate and potency of cancer therapies. Therefore, knowing how specific extracellular matrix (ECM) and cellular components regulate transport in the tumor interstitium could lead to matrix normalizing strategies that improve patient outcome. Studies over the past decades have provided quantitative insights into interstitial transport in tumors by characterizing two governing parameters: (1) molecular diffusivity and (2) hydraulic conductivity. However, many of the conventional techniques used to measure these parameters are limited due to their inability to experimentally manipulate the physical and cellular environments of tumors. Here, we examine the application and future opportunities of microfluidic systems for identifying the physiochemical mediators of mass transport in the tumor ECM. Further advancement and adoption of microfluidic systems to quantify tumor transport parameters has potential to bridge basic science with translational research for advancing personalized medicine in oncology. Frontiers Media S.A. 2019-01-23 /pmc/articles/PMC6364047/ /pubmed/30761297 http://dx.doi.org/10.3389/fbioe.2019.00006 Text en Copyright © 2019 Avendano, Cortes-Medina and Song. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Avendano, Alex
Cortes-Medina, Marcos
Song, Jonathan W.
Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix
title Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix
title_full Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix
title_fullStr Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix
title_full_unstemmed Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix
title_short Application of 3-D Microfluidic Models for Studying Mass Transport Properties of the Tumor Interstitial Matrix
title_sort application of 3-d microfluidic models for studying mass transport properties of the tumor interstitial matrix
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364047/
https://www.ncbi.nlm.nih.gov/pubmed/30761297
http://dx.doi.org/10.3389/fbioe.2019.00006
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