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The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries

BACKGROUND: Surface roughness can be used to identify disease within biological tissues. Quantifying surface roughness in the coronary arteries aids in developing treatments for coronary heart disease. This study investigates the effect of extreme physiological loading on surface roughness, for exam...

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Autores principales: Burton, Hanna E., Espino, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364105/
https://www.ncbi.nlm.nih.gov/pubmed/30809272
http://dx.doi.org/10.1155/2019/2784172
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author Burton, Hanna E.
Espino, Daniel M.
author_facet Burton, Hanna E.
Espino, Daniel M.
author_sort Burton, Hanna E.
collection PubMed
description BACKGROUND: Surface roughness can be used to identify disease within biological tissues. Quantifying surface roughness in the coronary arteries aids in developing treatments for coronary heart disease. This study investigates the effect of extreme physiological loading on surface roughness, for example, due to a rupture of an artery. METHODS: The porcine left anterior descending (LAD) coronary arteries were dissected ex vivo. Mechanical overloading was applied to the arteries in the longitudinal direction to simulate extreme physiological loading. Surface roughness was calculated from three-dimensional reconstructed images. Surface roughness was measured before and after damage and after chemical processing to dehydrate tissue specimens. RESULTS: Control specimens confirmed that dehydration alone results in an increase of surface roughness in the circumferential direction only. No variation was noted between the hydrated healthy and damaged specimens, in both the longitudinal (0.91 ± 0.26 and 1.05 ± 0.25 μm) and circumferential (1.46 ± 0.38 and 1.47 ± 0.39 μm) directions. After dehydration, an increase in surface roughness was noted for damaged specimens in both the longitudinal (1.28 ± 0.33 μm) and circumferential (1.95 ± 0.56 μm) directions. CONCLUSIONS: Mechanical overloading applied in the longitudinal direction did not significantly affect surface roughness. However, when combined with chemical processing, a significant increase in surface roughness was noted in both the circumferential and longitudinal directions. Mechanical overloading causes damage to the internal constituents of the arteries, which is significantly noticeable after dehydration of tissue.
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spelling pubmed-63641052019-02-26 The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries Burton, Hanna E. Espino, Daniel M. Appl Bionics Biomech Research Article BACKGROUND: Surface roughness can be used to identify disease within biological tissues. Quantifying surface roughness in the coronary arteries aids in developing treatments for coronary heart disease. This study investigates the effect of extreme physiological loading on surface roughness, for example, due to a rupture of an artery. METHODS: The porcine left anterior descending (LAD) coronary arteries were dissected ex vivo. Mechanical overloading was applied to the arteries in the longitudinal direction to simulate extreme physiological loading. Surface roughness was calculated from three-dimensional reconstructed images. Surface roughness was measured before and after damage and after chemical processing to dehydrate tissue specimens. RESULTS: Control specimens confirmed that dehydration alone results in an increase of surface roughness in the circumferential direction only. No variation was noted between the hydrated healthy and damaged specimens, in both the longitudinal (0.91 ± 0.26 and 1.05 ± 0.25 μm) and circumferential (1.46 ± 0.38 and 1.47 ± 0.39 μm) directions. After dehydration, an increase in surface roughness was noted for damaged specimens in both the longitudinal (1.28 ± 0.33 μm) and circumferential (1.95 ± 0.56 μm) directions. CONCLUSIONS: Mechanical overloading applied in the longitudinal direction did not significantly affect surface roughness. However, when combined with chemical processing, a significant increase in surface roughness was noted in both the circumferential and longitudinal directions. Mechanical overloading causes damage to the internal constituents of the arteries, which is significantly noticeable after dehydration of tissue. Hindawi 2019-01-23 /pmc/articles/PMC6364105/ /pubmed/30809272 http://dx.doi.org/10.1155/2019/2784172 Text en Copyright © 2019 Hanna E. Burton and Daniel M. Espino. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Burton, Hanna E.
Espino, Daniel M.
The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries
title The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries
title_full The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries
title_fullStr The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries
title_full_unstemmed The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries
title_short The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries
title_sort effect of mechanical overloading on surface roughness of the coronary arteries
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364105/
https://www.ncbi.nlm.nih.gov/pubmed/30809272
http://dx.doi.org/10.1155/2019/2784172
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