Diffuse Alveolar Hemorrhage Caused by Warfarin after Rifampicin Discontinuation

An 83-year-old man under warfarin therapy presented for assessment of prolonged prothrombin time and cough. High-resolution computed tomography findings of the chest showed diffuse alveolar hemorrhage. His international normalized ratio (INR) was 11.89. He had been treated with rifampicin for a pers...

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Detalles Bibliográficos
Autores principales: Kiyota, Takashige, Shiota, Seiji, Hamanaka, Ryosuke, Tsutsumi, Daisuke, Takakura, Takeshi, Miyazaki, Eishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364120/
https://www.ncbi.nlm.nih.gov/pubmed/30809261
http://dx.doi.org/10.1155/2019/4917856
Descripción
Sumario:An 83-year-old man under warfarin therapy presented for assessment of prolonged prothrombin time and cough. High-resolution computed tomography findings of the chest showed diffuse alveolar hemorrhage. His international normalized ratio (INR) was 11.89. He had been treated with rifampicin for a persistent infection, but this had been discontinued about two months before admission. Rifampicin suppresses the anticoagulant activity of warfarin, which can lead to a need for increased doses of warfarin to achieve and maintain a therapeutic INR. More frequent INR monitoring is needed even after discontinuing rifampicin.

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