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Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns

BACKGROUND: Newborn telomere length (TL) is considered a potential marker for future disease and lifelong health, but few epidemiological studies have examined the determinants of TL in early life. The study aim was to investigate whether there is an association between prenatal cadmium exposure and...

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Autores principales: Zhang, Lina, Song, Lulu, Liu, Bingqing, Wu, Mingyang, Wang, Lulin, Zhang, Bin, Xiong, Chao, Xia, Wei, Li, Yuanyuan, Cao, Zhongqiang, Wang, Youjie, Xu, Shunqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364384/
https://www.ncbi.nlm.nih.gov/pubmed/30722777
http://dx.doi.org/10.1186/s12916-019-1262-4
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author Zhang, Lina
Song, Lulu
Liu, Bingqing
Wu, Mingyang
Wang, Lulin
Zhang, Bin
Xiong, Chao
Xia, Wei
Li, Yuanyuan
Cao, Zhongqiang
Wang, Youjie
Xu, Shunqing
author_facet Zhang, Lina
Song, Lulu
Liu, Bingqing
Wu, Mingyang
Wang, Lulin
Zhang, Bin
Xiong, Chao
Xia, Wei
Li, Yuanyuan
Cao, Zhongqiang
Wang, Youjie
Xu, Shunqing
author_sort Zhang, Lina
collection PubMed
description BACKGROUND: Newborn telomere length (TL) is considered a potential marker for future disease and lifelong health, but few epidemiological studies have examined the determinants of TL in early life. The study aim was to investigate whether there is an association between prenatal cadmium exposure and relative cord blood TL in Chinese newborns. METHODS: Participants were 410 mother–newborn pairs drawn from a prospective birth cohort study conducted in Wuhan, China, between November 2013 and March 2015. Urine samples were collected from pregnant women during their period of institutional delivery. Urinary cadmium concentrations were measured by inductively coupled plasma mass spectrometry. The real-time quantitative polymerase chain reaction detection was used to measure relative TL using genomic DNA isolated from umbilical cord blood leukocytes. Multivariate linear regression models were used to estimate the effect of prenatal urinary cadmium concentration on relative cord blood TL. RESULTS: The geometric mean of maternal urinary cadmium concentration was 0.68 μg/g creatinine. In the multivariate-adjusted linear regression model, per doubling of maternal urinary cadmium concentration was associated with 6.83% (95% CI − 11.44%, − 1.97%; P = 0.006) shorter relative cord blood TL. Stratified analyses indicated that the inverse association between prenatal urinary cadmium and newborn relative TL was more pronounced among female infants and mothers < 29 years, while there were no significant effect modification according to infant sex (P for interaction = 0.907) and maternal age (P for interaction = 0.797). CONCLUSIONS: The findings indicated that increased maternal urinary cadmium was associated with shortened relative cord blood TL. The results provide more evidence of the negative effects of environmental cadmium exposure and suggest that accelerated aging or cadmium-related diseases may begin in early life.
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spelling pubmed-63643842019-02-15 Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns Zhang, Lina Song, Lulu Liu, Bingqing Wu, Mingyang Wang, Lulin Zhang, Bin Xiong, Chao Xia, Wei Li, Yuanyuan Cao, Zhongqiang Wang, Youjie Xu, Shunqing BMC Med Research Article BACKGROUND: Newborn telomere length (TL) is considered a potential marker for future disease and lifelong health, but few epidemiological studies have examined the determinants of TL in early life. The study aim was to investigate whether there is an association between prenatal cadmium exposure and relative cord blood TL in Chinese newborns. METHODS: Participants were 410 mother–newborn pairs drawn from a prospective birth cohort study conducted in Wuhan, China, between November 2013 and March 2015. Urine samples were collected from pregnant women during their period of institutional delivery. Urinary cadmium concentrations were measured by inductively coupled plasma mass spectrometry. The real-time quantitative polymerase chain reaction detection was used to measure relative TL using genomic DNA isolated from umbilical cord blood leukocytes. Multivariate linear regression models were used to estimate the effect of prenatal urinary cadmium concentration on relative cord blood TL. RESULTS: The geometric mean of maternal urinary cadmium concentration was 0.68 μg/g creatinine. In the multivariate-adjusted linear regression model, per doubling of maternal urinary cadmium concentration was associated with 6.83% (95% CI − 11.44%, − 1.97%; P = 0.006) shorter relative cord blood TL. Stratified analyses indicated that the inverse association between prenatal urinary cadmium and newborn relative TL was more pronounced among female infants and mothers < 29 years, while there were no significant effect modification according to infant sex (P for interaction = 0.907) and maternal age (P for interaction = 0.797). CONCLUSIONS: The findings indicated that increased maternal urinary cadmium was associated with shortened relative cord blood TL. The results provide more evidence of the negative effects of environmental cadmium exposure and suggest that accelerated aging or cadmium-related diseases may begin in early life. BioMed Central 2019-02-06 /pmc/articles/PMC6364384/ /pubmed/30722777 http://dx.doi.org/10.1186/s12916-019-1262-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Zhang, Lina
Song, Lulu
Liu, Bingqing
Wu, Mingyang
Wang, Lulin
Zhang, Bin
Xiong, Chao
Xia, Wei
Li, Yuanyuan
Cao, Zhongqiang
Wang, Youjie
Xu, Shunqing
Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns
title Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns
title_full Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns
title_fullStr Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns
title_full_unstemmed Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns
title_short Prenatal cadmium exposure is associated with shorter leukocyte telomere length in Chinese newborns
title_sort prenatal cadmium exposure is associated with shorter leukocyte telomere length in chinese newborns
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364384/
https://www.ncbi.nlm.nih.gov/pubmed/30722777
http://dx.doi.org/10.1186/s12916-019-1262-4
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