Kinase inhibitor library screening identifies synergistic drug combinations effective in sensitive and resistant melanoma cells

BACKGROUND: Melanoma is the most aggressive and deadly form of skin cancer with increasing case numbers worldwide. The development of inhibitors targeting mutated BRAF (found in around 60% of melanoma patients) has markedly improved overall survival of patients with late-stage tumors, even more so w...

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Detalles Bibliográficos
Autores principales: Margue, Christiane, Philippidou, Demetra, Kozar, Ines, Cesi, Giulia, Felten, Paul, Kulms, Dagmar, Letellier, Elisabeth, Haan, Claude, Kreis, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364417/
https://www.ncbi.nlm.nih.gov/pubmed/30728057
http://dx.doi.org/10.1186/s13046-019-1038-x

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